Tbio SPCS3 Signal peptidase complex subunit 3

Protein Summary

Description

Component of the microsomal signal peptidase complex which removes signal peptides and other N-terminal peptides from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum.

Uniprot Accession IDs

• P61009
• P12280
• Q9H0S7

Gene Name

• SPCS3

Ensembl ID

• ENST00000503362
• ENSP00000427463
• ENSG00000129128

Symbol

• SPC22
• SPC3
• PRO3567
• YLR066W
• SPC22/23

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	1
transcription factor perturbation	0.91
disease perturbation	0.9
microRNA	0.89
gene perturbation	0.76

Protein Classes

PANTHER Classes

Protein / Hydrolase / Protease / Signal Peptidase Complex Subunit 3

DTO Classes

Protein / Enzyme / Protease / Signal Peptidase Complex Subunit 3

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.42   (req: < 5)

Gene RIFs: 2   (req: <= 3)

Antibodies: 69   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.42   (req: >= 5)

Gene RIFs: 2   (req: > 3)

Antibodies: 69   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0