| Tbio | Glia maturation factor beta |
This protein causes differentiation of brain cells, stimulation of neural regeneration, and inhibition of proliferation of tumor cells.
Comments
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Multiple Sclerosis | 498 | 3.747 | 1.9 |
| Disease | log2 FC | p |
|---|---|---|
| cutaneous lupus erythematosus | 1.200 | 0.007 |
| psoriasis | 2.700 | 0.000 |
| osteosarcoma | 2.415 | 0.001 |
| atypical teratoid / rhabdoid tumor | 1.700 | 0.000 |
| glioblastoma | 1.800 | 0.000 |
| medulloblastoma | 1.400 | 0.000 |
| medulloblastoma, large-cell | 1.700 | 0.001 |
| primitive neuroectodermal tumor | 1.100 | 0.000 |
| acute quadriplegic myopathy | 1.158 | 0.000 |
| Atopic dermatitis | 1.100 | 0.000 |
| tuberculosis and treatment for 3 months | -1.300 | 0.000 |
| intraductal papillary-mucinous neoplasm ... | 1.500 | 0.042 |
| lung cancer | 1.400 | 0.010 |
| diabetes mellitus | -1.100 | 0.008 |
| pediatric high grade glioma | 1.200 | 0.002 |
| pilocytic astrocytoma | 1.200 | 0.001 |
| aldosterone-producing adenoma | -1.140 | 0.024 |
| breast carcinoma | 1.200 | 0.000 |
| progressive supranuclear palsy | -1.100 | 0.032 |
| ductal carcinoma in situ | 1.200 | 0.001 |
| invasive ductal carcinoma | 1.900 | 0.000 |
| ovarian cancer | -2.200 | 0.000 |
| Down syndrome | 1.500 | 0.001 |
| Species | Source |
|---|---|
| Chimp | OMA EggNOG |
| Macaque | OMA EggNOG |
| Mouse | OMA EggNOG Inparanoid |
| Rat | OMA Inparanoid |
| Dog | OMA Inparanoid |
| Horse | OMA EggNOG Inparanoid |
| Cow | OMA EggNOG Inparanoid |
| Pig | OMA EggNOG Inparanoid |
| Opossum | EggNOG Inparanoid |
| Platypus | OMA EggNOG |
| Chicken | OMA Inparanoid |
| Anole lizard | OMA EggNOG Inparanoid |
| Xenopus | OMA EggNOG Inparanoid |
| Zebrafish | OMA EggNOG Inparanoid |
| PMID | Text |
|---|---|
| 22035352 | The distribution of GMF-immunoreactive cells in and around amyloid plaques and neurofibrillary tangles suggests involvement of GMF in inflammatory responses through reactive glia and a role of GMF in Alzheimer disease pathology. |
| 21835226 | GMF co-localizes with amyloid plaques and neurofibrillary tangles in Alzheimer brains, implicating significant upregulation of GMF expression under conditions of neurodegeneration. |
| 19086053 | Observational study of gene-disease association. (HuGE Navigator) |
| 18171522 | There is a significant increase in GMF beta protein expression levels in IFN beta-1a treated LX-2 cells. |
| 16115230 | GMFB promoted T-cell differentiation into CD4-/CD8+ cells when analysed by two-colour flow cytometry. |
| PMID | Year | Title |
|---|---|---|
| 24275569 | 2014 | An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. |
| 23259602 | 2012 | Genome-wide association scan of dental caries in the permanent dentition. |
| 22814378 | 2012 | N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB. |
| 22223895 | 2012 | Comparative large scale characterization of plant versus mammal proteins reveals similar and idiosyncratic N-?-acetylation features. |
| 22035352 | 2012 | Expression of glia maturation factor in neuropathological lesions of Alzheimer's disease. |
| 21835226 | 2011 | Augmented expression of glia maturation factor in Alzheimer's disease. |
| 21269460 | 2011 | Initial characterization of the human central proteome. |
| 20547056 | 2010 | Identification of glia maturation factor beta as an independent prognostic predictor for serous ovarian cancer. |
| 19413330 | 2009 | Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. |
| 19086053 | 2009 | Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment. |
| More... |
