SEC61G
Protein transport protein Sec61 subunit gamma
Protein Summary
Component of SEC61 channel-forming translocon complex that mediates transport of signal peptide-containing precursor polypeptides across endoplasmic reticulum (ER). The Sec61 complex is the central component of the protein translocation apparatus of the endoplasmic reticulum (ER) membrane. Oligomers of the Sec61 complex form a transmembrane channel where proteins are translocated across and integrated into the ER membrane. This complex consists of three membrane proteins- alpha, beta, and gamma. This gene encodes the gamma-subunit protein. Alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008]
- ENST00000352861
- ENSP00000341538
- ENSG00000132432
- ENST00000395535
- ENSP00000378906
- ENST00000415949
- ENSP00000388337
- ENST00000450622
- ENSP00000409884
- SSS1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
histone modification site profile | 0.86 | ||
disease perturbation | 0.83 | ||
transcription factor binding site profile | 0.78 | ||
interacting protein | 0.71 | ||
virus perturbation | 0.64 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 16.47 (req: < 5)
Gene RIFs: 12 (req: <= 3)
Antibodies: 58 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 16.47 (req: >= 5)
Gene RIFs: 12 (req: > 3)
Antibodies: 58 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 3
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0