Tchem TAS2R20 Taste receptor type 2 member 20

Protein Summary

Description

Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 (By similarity). This gene encodes a member of the taste receptor two family of class C G-protein coupled receptors. Receptors of this family have a short extracellular N-terminus, seven transmembrane helices, three extracellular loops and three intracellular loops, and an intracellular C-terminus. Members of this family are expressed in a subset of taste receptor cells, where they function in bitter taste reception, as well as in non-gustatory cells including those of the brain, reproductive organs, respiratory system, and gastrointestinal system. This gene maps to the taste receptor gene cluster on chromosome 12p13. [provided by RefSeq, Jul 2016]

Uniprot Accession IDs

• P59543
• P59549
• Q2HIZ4
• Q496D8
• Q645X9

Gene Name

• TAS2R20

Ensembl ID

• ENST00000538986
• ENSP00000441624
• ENSG00000255837
• ENST00000570941
• ENSP00000459353
• ENSG00000273092

Symbol

• TAS2R49
• T2R20
• T2R49
• T2R56
• TAS2R49

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
cell line	0.58
microRNA	0.55
tissue sample	0.52
tissue	0.48
pathway	0.44

Protein Classes

DTO Classes

Protein / G-protein Coupled Receptor / Class A Rhodopsin Like / Taste 2 Receptor / Taste Receptor Type 2 Member 20

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.29   (req: < 5)

Gene RIFs: 0   (req: <= 3)

Antibodies: 79   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.29   (req: >= 5)

Gene RIFs: 0   (req: > 3)

Antibodies: 79   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1