Tchem TAS2R43 Taste receptor type 2 member 43

Protein Summary

Description

Gustducin-coupled receptor immplicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5. Activated by the sulfonyl amide sweeteners saccharin and acesulfame K. In airway epithelial cells, binding of bitter compounds increases the intracellular calcium ion concentration and stimulates ciliary beat frequency. May act as chemosensory receptors in airway epithelial cells to detect and eliminate potential noxious agents from the airways (By similarity). TAS2R43 belongs to the large TAS2R receptor family. TAS2Rs are expressed on the surface of taste receptor cells and mediate the perception of bitterness through a G protein-coupled second messenger pathway (Conte et al., 2002 [PubMed 12584440]). For further information on TAS2Rs, see MIM 604791.[supplied by OMIM, Mar 2009]

Uniprot Accession IDs

• P59537
• P59546
• Q645X4
• T2R43

Gene Name

• TAS2R43

Ensembl ID

• ENST00000531678
• ENSP00000431719
• ENSG00000255374
• ENST00000571879
• ENSP00000458723
• ENSG00000262612

Symbol

• T2R43
• T2R52

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
tissue sample	0.48
cellular component	0.41
pathway	0.38
biological term	0.37
cell line	0.37

Protein Classes

DTO Classes

Protein / G-protein Coupled Receptor / Class A Rhodopsin Like / Taste 2 Receptor / Taste Receptor Type 2 Member 43

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.4   (req: < 5)

Gene RIFs: 10   (req: <= 3)

Antibodies: 62   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.4   (req: >= 5)

Gene RIFs: 10   (req: > 3)

Antibodies: 62   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1