Tchem TAS2R38 Taste receptor type 2 member 38

Protein Summary

Description

Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 (By similarity). This gene encodes a seven-transmembrane G protein-coupled receptor that controls the ability to taste glucosinolates, a family of bitter-tasting compounds found in plants of the Brassica sp. Synthetic compounds phenylthiocarbamide (PTC) and 6-n-propylthiouracil (PROP) have been identified as ligands for this receptor and have been used to test the genetic diversity of this gene. Although several allelic forms of this gene have been identified worldwide, there are two predominant common forms (taster and non-taster) found outside of Africa. These alleles differ at three nucleotide positions resulting in amino acid changes in the protein (A49P, A262V, and V296I) with the amino acid combination PAV identifying the taster variant (and AVI identifying the non-taster variant). [provided by RefSeq, Oct 2009]

Uniprot Accession IDs

• P59533
• A4D1U6
• P59552
• Q2M3E8
• Q645W3
• Q86UK3
• T2R38

Gene Name

• TAS2R38

Ensembl ID

• ENST00000547270
• ENSP00000448219
• ENSG00000257138

Symbol

• PTC
• PTC
• T2R38
• T2R61
• THIOT

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
tissue	0.63
biological term	0.61
tissue sample	0.57
cell line	0.55
phenotype	0.49

Protein Classes

DTO Classes

Protein / G-protein Coupled Receptor / Class A Rhodopsin Like / Taste 2 Receptor / Taste Receptor Type 2 Member 38

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 278.41   (req: < 5)

Gene RIFs: 119   (req: <= 3)

Antibodies: 113   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 278.41   (req: >= 5)

Gene RIFs: 119   (req: > 3)

Antibodies: 113   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1