Property Summary

NCBI Gene PubMed Count 12
PubMed Score 13.41
PubTator Score 4.99

Knowledge Summary

Patent

No data available

Expression

  Differential Expression (6)

Disease log2 FC p
cutaneous lupus erythematosus 1.300 0.007
psoriasis 1.400 0.000
osteosarcoma -1.041 0.000
tuberculosis 1.100 0.000
ovarian cancer 1.400 0.000
pituitary cancer -1.300 0.000

Synonym

Accession P57764 A8K702 D3DWJ9 Q96Q98
Symbols DF5L
DFNA5L
FKSG10
GSDMDC1

Gene

Gene RIF (4)

PMID Text
27383986 GSDMD N-terminal cleavage product oligomerizes in membranes to form pores that are visible by electron microscopy
26611636 Gene deletion of GSDMD demonstrated that GSDMD is required for pyroptosis and for the secretion but not proteolytic maturation of IL-1beta in both canonical and non-canonical inflammasome responses.
26375003 caspase-1 and caspase-4/5/11 specifically cleaved the linker between the amino-terminal gasdermin-N and carboxy-terminal gasdermin-C domains in GSDMD, which was required and sufficient for pyroptosis
19051310 Study investigated the expression pattern of the GSDM family genes in the upper gastrointestinal epithelium and cancers.

AA Sequence

MGSAFERVVRRVVQELDHGGEFIPVTSLQSSTGFQPYCLVVRKPSSSWFWKPRYKCVNLSIKDILEPDAA      1 - 70
EPDVQRGRSFHFYDAMDGQIQGSVELAAPGQAKIAGGAAVSDSSSTSMNVYSLSVDPNTWQTLLHERHLR     71 - 140
QPEHKVLQQLRSRGDNVYVVTEVLQTQKEVEVTRTHKREGSGRFSLPGATCLQGEGQGHLSQKKTVTIPS    141 - 210
GSTLAFRVAQLVIDSDLDVLLFPDKKQRTFQPPATGHKRSTSEGAWPQLPSGLSMMRCLHNFLTDGVPAE    211 - 280
GAFTEDFQGLRAEVETISKELELLDRELCQLLLEGLEGVLRDQLALRALEEALEQGQSLGPVEPLDGPAG    281 - 350
AVLECLVLSSGMLVPELAIPVVYLLGALTMLSETQHKLLAEALESQTLLGPLELVGSLLEQSAPWQERST    351 - 420
MSLPPGLLGNSWGEGAPAWVLLDECGLELGEDTPHVCWEPQAQGRMCALYASLALLSGLSQEPH          421 - 484
//

Text Mined References (21)

PMID Year Title
27418190 2016 GSDMD membrane pore formation constitutes the mechanism of pyroptotic cell death.
27383986 2016 Inflammasome-activated gasdermin D causes pyroptosis by forming membrane pores.
27281216 2016 Pore-forming activity and structural autoinhibition of the gasdermin family.
26611636 2015 Gasdermin D is an executor of pyroptosis and required for interleukin-1? secretion.
26375259 2015 Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling.
26375003 2015 Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death.
25944712 2015 N-terminome analysis of the human mitochondrial proteome.
25416956 2014 A proteome-scale map of the human interactome network.
24275569 2014 An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
23186163 2013 Toward a comprehensive characterization of a human cancer cell phosphoproteome.
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