Property Summary

NCBI Gene PubMed Count 20
Grant Count 8
R01 Count 5
Funding $1,019,064.85
PubMed Score 22.92
PubTator Score 21.35

Knowledge Summary

Patent

No data available

Expression

  Differential Expression (4)

Disease log2 FC p
posterior fossa group B ependymoma -1.300 0.000
group 3 medulloblastoma 2.000 0.001
medulloblastoma, large-cell 1.600 0.003
lung cancer 1.200 0.000

Gene RIF (4)

PMID Text
26196957 PCBP4 plays important roles in the induction of cisplatin resistance in human maxillary cancers.
20628086 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
19913121 Observational study of gene-disease association. (HuGE Navigator)
17973258 expression of alpha CP-4 can inhibit proliferation and tumorigenesis of lung cancer cells, both in vivo and in vitro, by delaying the progression of the cell cycle

AA Sequence

MSGSDGGLEEEPELSITLTLRMLMHGKEVGSIIGKKGETVKRIREQSSARITISEGSCPERITTITGSTA      1 - 70
AVFHAVSMIAFKLDEDLCAAPANGGNVSRPPVTLRLVIPASQCGSLIGKAGTKIKEIRETTGAQVQVAGD     71 - 140
LLPNSTERAVTVSGVPDAIILCVRQICAVILESPPKGATIPYHPSLSLGTVLLSANQGFSVQGQYGAVTP    141 - 210
AEVTKLQQLSSHAVPFATPSVVPGLDPGTQTSSQEFLVPNDLIGCVIGRQGSKISEIRQMSGAHIKIGNQ    211 - 280
AEGAGERHVTITGSPVSIALAQYLITACLETAKSTSGGTPSSAPADLPAPFSPPLTALPTAPPGLLGTPY    281 - 350
AISLSNFIGLKPMPFLALPPASPGPPPGLAAYTAKMAAANGSKKAERQKFSPY                     351 - 403
//

Text Mined References (20)

PMID Year Title
26196957 2015 Suppression of Poly(rC)-Binding Protein 4 (PCBP4) reduced cisplatin resistance in human maxillary cancer cells.
22658674 2012 Insights into RNA biology from an atlas of mammalian mRNA-binding proteins.
20817677 2011 The cyclin-dependent kinase inhibitor p21 is regulated by RNA-binding protein PCBP4 via mRNA stability.
20628086 2010 Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
19913121 2009 Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
17973258 2008 Expression of alpha CP-4 inhibits cell cycle progression and suppresses tumorigenicity of lung cancer cells.
16713569 2006 A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration.
16344560 2006 Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.
15489334 2004 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
15205328 2004 Alpha CP-4, encoded by a putative tumor suppressor gene at 3p21, but not its alternative splice variant alpha CP-4a, is underexpressed in lung cancer.
14702039 2004 Complete sequencing and characterization of 21,243 full-length human cDNAs.
14612387 2003 A novel set of nuclear localization signals determine distributions of the alphaCP RNA-binding proteins.
12477932 2002 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
12003487 2002 The poly(C)-binding proteins: a multiplicity of functions and a search for mechanisms.
11984006 2002 The Chediak-Higashi protein interacts with SNARE complex and signal transduction proteins.
11313928 2001 Regulation of the G2/M transition by p53.
10936052 2000 Identification of two novel mammalian genes establishes a subfamily of KH-domain RNA-binding proteins.
10891498 2000 MCG10, a novel p53 target gene that encodes a KH domain RNA-binding protein, is capable of inducing apoptosis and cell cycle arrest in G(2)-M.
8889548 1996 Normalization and subtraction: two approaches to facilitate gene discovery.
8125298 1994 Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.