Tchem RIPK4 Receptor-interacting serine/threonine-protein kinase 4

Protein Summary

Description

Involved in stratified epithelial development. It is a direct transcriptional target of TP63. Plays a role in NF-kappa-B activation. The protein encoded by this gene is a serine/threonine protein kinase that interacts with protein kinase C-delta. The encoded protein can also activate NFkappaB and is required for keratinocyte differentiation. This kinase undergoes autophosphorylation. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P57078
• Q96KH0

Gene Name

• RIPK4

Ensembl ID

• ENST00000332512
• ENSP00000332454
• ENSG00000183421
• ENST00000352483
• ENSP00000330161

Symbol

• ANKRD3
• DIK
• DIK
• PKK
• PPS2
• RIP4
• ANKK2
• NKRD3
• ANKRD3
• CHANDS

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
PubMedID	0.78
virus perturbation	0.68
gene perturbation	0.67
transcription factor binding site profile	0.67
transcription factor perturbation	0.61

Protein Classes

DTO Classes

Protein / Kinase / Protein Kinase / Tkl Group / Ripk Family / Receptor-interacting Serine/threonine-protein Kinase 4

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 192.76   (req: < 5)

Gene RIFs: 40   (req: <= 3)

Antibodies: 284   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 192.76   (req: >= 5)

Gene RIFs: 40   (req: > 3)

Antibodies: 284   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0