Property Summary

NCBI Gene PubMed Count 10
Grant Count 38
R01 Count 5
Funding $18,972,972
PubMed Score 56.95
PubTator Score 12.64

Knowledge Summary

Patent

No data available

Expression

  Differential Expression (6)

Disease log2 FC p
Down syndrome 1.100 0.001
Multiple myeloma 1.741 0.002
osteosarcoma 1.221 0.011
primary pancreatic ductal adenocarcinoma -1.258 0.005
lung cancer 1.200 0.026
pancreatic cancer -1.300 0.003

Gene RIF (2)

PMID Text
20379614 Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
11331941 Results in mouse suggest that this is the only gene from the Down Syndrome Critical Region expressed in the developing tongue and that the encoded protein may be involved in pathophysiology of tongue malformation seen in Down syndrome.

AA Sequence

MVPRSTSLALIVFLFHRLSKAPGKMVENSPSPLPERAIYGFVLFLSSQFGFILYLVWAFIPESWLNSLGL      1 - 70
TYWPQKYWAVALPVYLLIAIVIGYVLLFGINMMSTSPLDSIHTITDNYAKNQQQKKYQEEAIPALRDISI     71 - 140
SEVNQMFFLAAKELYTKN                                                        141 - 158
//

Text Mined References (12)

PMID Year Title
20379614 Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
19054851 2008 Human protein factory for converting the transcriptome into an in vitro-expressed proteome,.
15489334 2004 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
15221505 2004 Protein levels of genes encoded on chromosome 21 in fetal Down Syndrome brain (Part V): overexpression of phosphatidyl-inositol-glycan class P protein (DSCR5).
14702039 2004 Complete sequencing and characterization of 21,243 full-length human cDNAs.
12477932 2002 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
11331941 2001 Molecular cloning and characterization of a gene expressed in mouse developing tongue, mDscr5 gene, a homolog of human DSCR5 (Down syndrome Critical Region gene 5).
11102867 2000 Dissecting and manipulating the pathway for glycosylphos-phatidylinositol-anchor biosynthesis.
10944123 2000 Initial enzyme for glycosylphosphatidylinositol biosynthesis requires PIG-P and is regulated by DPM2.
10907851 2000 A novel gene, DSCR5, from the distal Down syndrome critical region on chromosome 21q22.2.
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