| Tbio | Breast cancer anti-estrogen resistance protein 1 |
Docking protein which plays a central coordinating role for tyrosine kinase-based signaling related to cell adhesion. Implicated in induction of cell migration. Overexpression confers antiestrogen resistance on breast cancer cells.
BCAR1, or CAS, is an Src (MIM 190090) family kinase substrate involved in various cellular events, including migration, survival, transformation, and invasion (Sawada et al., 2006 [PubMed 17129785]).[supplied by OMIM, May 2009]
BCAR1, or CAS, is an Src (MIM 190090) family kinase substrate involved in various cellular events, including migration, survival, transformation, and invasion (Sawada et al., 2006 [PubMed 17129785]).[supplied by OMIM, May 2009]
Comments
Property Summary
| NCBI Gene PubMed Count | 152 |
| Grant Count | 208 |
| R01 Count | 155 |
| Funding | $12,121,620.83 |
| PubMed Score | 211.22 |
| PubTator Score | 431.34 |
| Disease | Z-score | Confidence |
|---|---|---|
| Cancer 2,346 | 4.306 | 2.2 |
| Malignant neoplasm of pancreas 14 | ||
| Neoplasm Invasiveness 127 | ||
| Pancreatic Neoplasm 79 | ||
| osteosarcoma 7,933 |
| PMID | Text |
|---|---|
| 27068854 | blockade of GD3-mediated growth signaling pathways by siRNAs might be a novel and promising therapeutic strategy against malignant melanomas, provided signaling molecules such as p130Cas and paxillin are significantly expressed in individual cases. |
| 26716506 | Elevated levels of p130Cas is associated with trastuzumab resistance in breast cancer. |
| 26276885 | expression quantitative trait loci studies implicate BCAR1 as the causal gene of coronary artery disease Carotid intima-media thickness |
| 25805500 | p130(Cas) exon 1 variants display altered functional properties; shorter 1B isoform exhibited diminished FAK binding activity + reduced cell migration + invasion; longest variant 1B1 exhibited the most efficient FAK binding + greatly enhanced migration |
| 25727852 | BCAR1 has a pivotal role in the regulation of tissue homeostasis in pathological conditions such as cancer. (Review) |
| 25253349 | Collectively, these studies demonstrate that p130Cas acts as a bridging molecule between the Kaposi's sarcoma-associated herpesvirus-induced entry signal complex and the downstream trafficking signalosome in endothelial cells. |
| 24928898 | Cas promotes cell migration by linking actomyosin contractions to the adhesion complexes through interaction with Src and the actin cytoskeleton. |
| 24584939 | BCAR1 and BCAR3 scaffolding proteins have roles in cell signaling and antiestrogen resistance |
| 24494199 | Data introduce hitherto unappreciated paradigms whereby reactive oxygen species can reciprocally regulate the cellular localization of pro- and anti-migratory signaling molecules, p130cas and PTEN, respectively. |
| 24284072 | Our results show that endogenous Cul5 suppresses epithelial cell transformation by several pathways, including inhibition of Src-Cas-induced ruffling through SOCS6 |
| More... |
MNHLNVLAKALYDNVAESPDELSFRKGDIMTVLEQDTQGLDGWWLCSLHGRQGIVPGNRLKILVGMYDKK 1 - 70 PAGPGPGPPATPAQPQPGLHAPAPPASQYTPMLPNTYQPQPDSVYLVPTPSKAQQGLYQVPGPSPQFQSP 71 - 140 PAKQTSTFSKQTPHHPFPSPATDLYQVPPGPGGPAQDIYQVPPSAGMGHDIYQVPPSMDTRSWEGTKPPA 141 - 210 KVVVPTRVGQGYVYEAAQPEQDEYDIPRHLLAPGPQDIYDVPPVRGLLPSQYGQEVYDTPPMAVKGPNGR 211 - 280 DPLLEVYDVPPSVEKGLPPSNHHAVYDVPPSVSKDVPDGPLLREETYDVPPAFAKAKPFDPARTPLVLAA 281 - 350 PPPDSPPAEDVYDVPPPAPDLYDVPPGLRRPGPGTLYDVPRERVLPPEVADGGVVDSGVYAVPPPAEREA 351 - 420 PAEGKRLSASSTGSTRSSQSASSLEVAGPGREPLELEVAVEALARLQQGVSATVAHLLDLAGSAGATGSW 421 - 490 RSPSEPQEPLVQDLQAAVAAVQSAVHELLEFARSAVGNAAHTSDRALHAKLSRQLQKMEDVHQTLVAHGQ 491 - 560 ALDAGRGGSGATLEDLDRLVACSRAVPEDAKQLASFLHGNASLLFRRTKATAPGPEGGGTLHPNPTDKTS 561 - 630 SIQSRPLPSPPKFTSQDSPDGQYENSEGGWMEDYDYVHLQGKEEFEKTQKELLEKGSITRQGKSQLELQQ 631 - 700 LKQFERLEQEVSRPIDHDLANWTPAQPLAPGRTGGLGPSDRQLLLFYLEQCEANLTTLTNAVDAFFTAVA 701 - 770 TNQPPKIFVAHSKFVILSAHKLVFIGDTLSRQAKAADVRSQVTHYSNLLCDLLRGIVATTKAAALQYPSP 771 - 840 SAAQDMVERVKELGHSTQQFRRVLGQLAAA 841 - 870 //
| PMID | Year | Title |
|---|---|---|
| 27068854 | 2016 | A therapeutic trial of human melanomas with combined small interfering RNAs targeting adaptor molecules p130Cas and paxillin activated under expression of ganglioside GD3. |
| 26716506 | 2016 | p130Cas scaffold protein regulates ErbB2 stability by altering breast cancer cell sensitivity to autophagy. |
| 26276885 | 2015 | Functional Analysis of a Carotid Intima-Media Thickness Locus Implicates BCAR1 and Suggests a Causal Variant. |
| 25805500 | 2015 | Identification of Novel Crk-associated Substrate (p130Cas) Variants with Functionally Distinct Focal Adhesion Kinase Binding Activities. |
| 25727852 | 2015 | p130Cas/BCAR1 scaffold protein in tissue homeostasis and pathogenesis. |
| 25253349 | 2014 | p130Cas scaffolds the signalosome to direct adaptor-effector cross talk during Kaposi's sarcoma-associated herpesvirus trafficking in human microvascular dermal endothelial cells. |
| 25086665 | 2014 | Genome-wide association study identifies multiple susceptibility loci for pancreatic cancer. |
| 24928898 | 2014 | Displacement of p130Cas from focal adhesions links actomyosin contraction to cell migration. |
| 24584939 | 2014 | Association of the breast cancer antiestrogen resistance protein 1 (BCAR1) and BCAR3 scaffolding proteins in cell signaling and antiestrogen resistance. |
| 24494199 | 2014 | Intracellular redox status controls membrane localization of pro- and anti-migratory signaling molecules. |
| More... |
