Property Summary

NCBI Gene PubMed Count 47
Grant Count 1
Funding $225,541.75
PubMed Score 60.06
PubTator Score 39.44

Knowledge Summary


No data available


  Disease Relevance (2)


  Differential Expression (2)

Disease log2 FC p
atypical teratoid / rhabdoid tumor 2.500 0.000
ovarian cancer 1.600 0.002


Accession P56747 B3KQP9 D3DUA5


PANTHER Protein Class (2)

 Grant Application (1)

Gene RIF (23)

26561856 Data show that claudin-6 (CLDN6) R209Q and occludin (OCLN) P24A mutations do not affect HCV pseudoparticles (HCVpp) entry.
26191261 The expression of ASK1 is correlated with the level of claudin-6 in cervical carcinoma cells and tissues.
24710653 High levels of CLDN6 are associated with non-small-cell lung cancer.
23919729 The expression of claudin-6 was down regulated in gastric cancer tissue.
23864633 Although claudin-6 and claudin-9 can serve as entry factors in cell lines, hepatitis C virus infection into human hepatocytes is not dependent on claudin-6 and claudin-9.
23778593 This work provides a proof of concept for the use of Claudin-6 to eliminate residual undifferentiated human pluripotent stem cells from culture.
23775920 Only some hepatitis C virus strains efficiently use CLDN6 for infection.
22925655 ASK1 signal may play a positive role in the inhibitory effect of claudin-6 in breast cancer.
22455563 Our results show that claudin-6 protein is significantly down-regulated in breast invasive ductal carcinomas
21989342 CLDN6 is not a specific biomarker for atypical teratoid rhabdoid tumors as it is expressed in a variety of other pediatric CNS and soft tissue tumors.

AA Sequence

PSEYPTKNYV                                                                211 - 220

Text Mined References (49)

PMID Year Title
26561856 2015 Claudin-6 and Occludin Natural Variants Found in a Patient Highly Exposed but Not Infected with Hepatitis C Virus (HCV) Do Not Confer HCV Resistance In Vitro.
26191261 2015 Expression of apoptosis signal-regulating kinase 1 is associated with tight junction protein claudin-6 in cervical carcinoma.
24710653 2014 Aberrantly activated claudin 6 and 18.2 as potential therapy targets in non-small-cell lung cancer.
23919729 2013 The distinct expression patterns of claudin-2, -6, and -11 between human gastric neoplasms and adjacent non-neoplastic tissues.
23864633 2013 Functional analysis of claudin-6 and claudin-9 as entry factors for hepatitis C virus infection of human hepatocytes by using monoclonal antibodies.
23778593 2013 Immunologic and chemical targeting of the tight-junction protein Claudin-6 eliminates tumorigenic human pluripotent stem cells.
23775920 2014 Isolate-dependent use of claudins for cell entry by hepatitis C virus.
22925655 2012 Apoptosis signal-regulating kinase 1 is associated with the effect of claudin-6 in breast cancer.
22455563 2012 The expression patterns and correlations of claudin-6, methy-CpG binding protein 2, DNA methyltransferase 1, histone deacetylase 1, acetyl-histone H3 and acetyl-histone H4 and their clinicopathological significance in breast invasive ductal carcinomas.
21989342 2012 Claudin-6 is a nonspecific marker for malignant rhabdoid and other pediatric tumors.