| Tchem | C-terminal-binding protein 2 |
This gene produces alternative transcripts encoding two distinct proteins. One protein is a transcriptional repressor, while the other isoform is a major component of specialized synapses known as synaptic ribbons. Both proteins contain a NAD+ binding domain similar to NAD+-dependent 2-hydroxyacid dehydrogenases. A portion of the 3' untranslated region was used to map this gene to chromosome 21q21.3; however, it was noted that similar loci elsewhere in the genome are likely. Blast analysis shows that this gene is present on chromosome 10. Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Feb 2014]
Comments
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Cell Transformation, Neoplastic | 97 | 0.0 | 0.0 |
| Neoplasm Invasiveness | 161 | 0.0 | 0.0 |
| Prostatic Neoplasms | 495 | 0.0 | 0.0 |
| Disease | Target Count | P-value |
|---|---|---|
| juvenile dermatomyositis | 1187 | 4.0e-09 |
| malignant mesothelioma | 3232 | 7.8e-07 |
| Pick disease | 1894 | 1.1e-04 |
| dermatomyositis | 966 | 5.3e-04 |
| intraductal papillary-mucinous carcinoma (IPMC) | 2989 | 5.7e-04 |
| osteosarcoma | 7950 | 6.6e-04 |
| psoriasis | 6694 | 8.0e-04 |
| primitive neuroectodermal tumor | 3035 | 8.0e-04 |
| oligodendroglioma | 2850 | 3.3e-03 |
| invasive ductal carcinoma | 2951 | 1.6e-02 |
| intraductal papillary-mucinous neoplasm (IPMN) | 3291 | 1.6e-02 |
| esophageal adenocarcinoma | 737 | 1.8e-02 |
| ependymoma | 4679 | 1.8e-02 |
| pancreatic ductal adenocarcinoma liver metastasis | 1962 | 2.2e-02 |
| Barrett's esophagus | 182 | 2.6e-02 |
| astrocytic glioma | 2597 | 4.3e-02 |
| group 3 medulloblastoma | 4104 | 4.8e-02 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Multiple Sclerosis | 540 | 0.0 | 1.0 |
| Prostate cancer | 175 | 0.0 | 2.4 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| autosomal recessive nonsyndromic deafness 9 | 6 | 3.8 | 1.9 |
| Congenital stationary night blindness | 29 | 3.42 | 1.7 |
| Disease | log2 FC | p |
|---|---|---|
| astrocytic glioma | 1.100 | 4.3e-02 |
| Barrett's esophagus | 1.200 | 2.6e-02 |
| dermatomyositis | 1.400 | 5.3e-04 |
| ependymoma | 1.200 | 1.8e-02 |
| esophageal adenocarcinoma | 1.800 | 1.8e-02 |
| group 3 medulloblastoma | 1.100 | 4.8e-02 |
| intraductal papillary-mucinous carcinoma... | 1.100 | 5.7e-04 |
| intraductal papillary-mucinous neoplasm ... | 1.200 | 1.6e-02 |
| invasive ductal carcinoma | 1.100 | 1.6e-02 |
| juvenile dermatomyositis | 1.271 | 4.0e-09 |
| malignant mesothelioma | 1.200 | 7.8e-07 |
| oligodendroglioma | 1.200 | 3.3e-03 |
| osteosarcoma | -1.237 | 6.6e-04 |
| pancreatic ductal adenocarcinoma liver m... | 1.166 | 2.2e-02 |
| Pick disease | 1.100 | 1.1e-04 |
| primitive neuroectodermal tumor | 1.100 | 8.0e-04 |
| psoriasis | 1.400 | 8.0e-04 |
| Species | Source | Disease |
|---|---|---|
| OMA EggNOG | ||
| Inparanoid EggNOG | ||
| Inparanoid EggNOG | ||
| Inparanoid OMA | ||
| Inparanoid OMA | ||
| Inparanoid OMA |
CHEMBL3797935
pIC50 6.05
CHEMBL3799251
pIC50 6.06
CHEMBL3799689
pIC50 6.14
CHEMBL3800187
pIC50 6.32
CHEMBL3800006
pIC50 6.50
CHEMBL3800609
pIC50 6.52
CHEMBL3797778
pIC50 6.62
CHEMBL3798669
pIC50 6.75
CHEMBL3799940
pIC50 6.77
MALVDKHKVKRQRLDRICEGIRPQIMNGPLHPRPLVALLDGRDCTVEMPILKDLATVAFCDAQSTQEIHE 1 - 70 KVLNEAVGAMMYHTITLTREDLEKFKALRVIVRIGSGYDNVDIKAAGELGIAVCNIPSAAVEETADSTIC 71 - 140 HILNLYRRNTWLYQALREGTRVQSVEQIREVASGAARIRGETLGLIGFGRTGQAVAVRAKAFGFSVIFYD 141 - 210 PYLQDGIERSLGVQRVYTLQDLLYQSDCVSLHCNLNEHNHHLINDFTIKQMRQGAFLVNAARGGLVDEKA 211 - 280 LAQALKEGRIRGAALDVHESEPFSFAQGPLKDAPNLICTPHTAWYSEQASLEMREAAATEIRRAITGRIP 281 - 350 ESLRNCVNKEFFVTSAPWSVIDQQAIHPELNGATYRYPPGIVGVAPGGLPAAMEGIIPGGIPVTHNLPTV 351 - 420 AHPSQAPSPNQPTKHGDNREHPNEQ 421 - 445 //
