ARPP19
cAMP-regulated phosphoprotein 19
Protein Summary
Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. When phosphorylated at Ser-62 during mitosis, specifically interacts with PPP2R2D (PR55-delta) and inhibits its activity, leading to inactivation of PP2A, an essential condition to keep cyclin-B1-CDK1 activity high during M phase. May indirectly enhance GAP-43 expression. The 19-kD cAMP-regulated phosphoprotein plays a role in regulating mitosis by inhibiting protein phosphatase-2A (PP2A; see MIM 176915) (summary by Gharbi-Ayachi et al., 2010 [PubMed 21164014]).[supplied by OMIM, Feb 2011]
- ENST00000249822
- ENSP00000249822
- ENSG00000128989
- ENST00000561650
- ENSP00000454234
- ENST00000563277
- ENSP00000455986
- ENST00000563566
- ENSP00000457631
- ENST00000566423
- ENSP00000455625
- ENST00000567669
- ENSP00000455151
- ENST00000568196
- ENSP00000457805
- ENST00000569281
- ENSP00000454297
- ENSAL
- ARPP16
- ARPP-16
- ARPP-19
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
virus perturbation | 0.94 | ||
kinase perturbation | 0.93 | ||
transcription factor perturbation | 0.88 | ||
disease perturbation | 0.87 | ||
microRNA | 0.87 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 41.82 (req: < 5)
Gene RIFs: 8 (req: <= 3)
Antibodies: 43 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 41.82 (req: >= 5)
Gene RIFs: 8 (req: > 3)
Antibodies: 43 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 12
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0