Tchem GFER FAD-linked sulfhydryl oxidase ALR

Protein Summary

Description

Isoform 1: FAD-dependent sulfhydryl oxidase that regenerates the redox-active disulfide bonds in CHCHD4/MIA40, a chaperone essential for disulfide bond formation and protein folding in the mitochondrial intermembrane space. The reduced form of CHCHD4/MIA40 forms a transient intermolecular disulfide bridge with GFER/ERV1, resulting in regeneration of the essential disulfide bonds in CHCHD4/MIA40, while GFER/ERV1 becomes re-oxidized by donating electrons to cytochrome c or molecular oxygen. Isoform 2: May act as an autocrine hepatotrophic growth factor promoting liver regeneration. The hepatotrophic factor designated augmenter of liver regeneration (ALR) is thought to be one of the factors responsible for the extraordinary regenerative capacity of mammalian liver. It has also been called hepatic regenerative stimulation substance (HSS). The gene resides on chromosome 16 in the interval containing the locus for polycystic kidney disease (PKD1). The putative gene product is 42% similar to the scERV1 protein of yeast. The yeast scERV1 gene had been found to be essential for oxidative phosphorylation, the maintenance of mitochondrial genomes, and the cell division cycle. The human gene is both the structural and functional homolog of the yeast scERV1 gene. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P55789
• Q53YM6
• Q8TAH6
• Q9H290
• Q9UK40

Gene Name

• GFER

Ensembl ID

• ENST00000248114
• ENSP00000248114
• ENSG00000127554

Symbol

• ALR
• HERV1
• HPO
• ALR
• HPO
• HSS
• ERV1
• HPO1
• HPO2
• HERV1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
virus perturbation	0.94
disease perturbation	0.87
histone modification site profile	0.84
transcription factor perturbation	0.8
molecular function	0.76

Protein Classes

PANTHER Classes

Protein / Oxidoreductase / Oxidase / Fad-linked Sulfhydryl Oxidase Alr

DTO Classes

Protein / Enzyme / Oxidoreductase / Oxidase / Fad-linked Sulfhydryl Oxidase Alr

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 382.59   (req: < 5)

Gene RIFs: 85   (req: <= 3)

Antibodies: 236   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 382.59   (req: >= 5)

Gene RIFs: 85   (req: > 3)

Antibodies: 236   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 449

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 4