| Tbio | C-C motif chemokine 23 |
Shows chemotactic activity for monocytes, resting T-lymphocytes, and neutrophils, but not for activated lymphocytes. Inhibits proliferation of myeloid progenitor cells in colony formation assays. This protein can bind heparin. Binds CCR1. CCL23(19-99), CCL23(22-99), CCL23(27-99), CCL23(30-99) are more potent chemoattractants than the small-inducible cytokine A23.
This gene is one of several chemokine genes clustered on the q-arm of chromosome 17. Chemokines form a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of the N-terminal cysteine residues of the mature peptide. This chemokine, a member of the CC subfamily, displays chemotactic activity on resting T lymphocytes and monocytes, lower activity on neutrophils and no activity on activated T lymphocytes. The protein is also a strong suppressor of colony formation by a multipotential hematopoietic progenitor cell line. In addition, the product of this gene is a potent agonist of the chemokine (C-C motif) receptor 1. Alternative splicing results in multiple transcript variants that encode different isoforms. [provided by RefSeq, Jul 2013]
This gene is one of several chemokine genes clustered on the q-arm of chromosome 17. Chemokines form a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of the N-terminal cysteine residues of the mature peptide. This chemokine, a member of the CC subfamily, displays chemotactic activity on resting T lymphocytes and monocytes, lower activity on neutrophils and no activity on activated T lymphocytes. The protein is also a strong suppressor of colony formation by a multipotential hematopoietic progenitor cell line. In addition, the product of this gene is a potent agonist of the chemokine (C-C motif) receptor 1. Alternative splicing results in multiple transcript variants that encode different isoforms. [provided by RefSeq, Jul 2013]
Comments
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Mesothelioma, Malignant | 105 | 0.0 | 0.0 |
| Disease | Target Count |
|---|---|
| malignant mesothelioma | 3232 |
| Disease | Target Count | P-value |
|---|---|---|
| non-small cell lung cancer | 2890 | 4.8e-15 |
| lung adenocarcinoma | 2716 | 2.4e-11 |
| osteosarcoma | 7950 | 3.4e-10 |
| interstitial cystitis | 2312 | 4.7e-02 |
| Disease | log2 FC | p |
|---|---|---|
| interstitial cystitis | 1.500 | 4.7e-02 |
| lung adenocarcinoma | -1.700 | 2.4e-11 |
| non-small cell lung cancer | -1.461 | 4.8e-15 |
| osteosarcoma | -3.688 | 3.4e-10 |
