| Tbio | C-C motif chemokine 23 |
Shows chemotactic activity for monocytes, resting T-lymphocytes, and neutrophils, but not for activated lymphocytes. Inhibits proliferation of myeloid progenitor cells in colony formation assays. This protein can bind heparin. Binds CCR1. CCL23(19-99), CCL23(22-99), CCL23(27-99), CCL23(30-99) are more potent chemoattractants than the small-inducible cytokine A23.
This gene is one of several chemokine genes clustered on the q-arm of chromosome 17. Chemokines form a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of the N-terminal cysteine residues of the mature peptide. This chemokine, a member of the CC subfamily, displays chemotactic activity on resting T lymphocytes and monocytes, lower activity on neutrophils and no activity on activated T lymphocytes. The protein is also a strong suppressor of colony formation by a multipotential hematopoietic progenitor cell line. In addition, the product of this gene is a potent agonist of the chemokine (C-C motif) receptor 1. Alternative splicing results in multiple transcript variants that encode different isoforms. [provided by RefSeq, Jul 2013]
This gene is one of several chemokine genes clustered on the q-arm of chromosome 17. Chemokines form a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of the N-terminal cysteine residues of the mature peptide. This chemokine, a member of the CC subfamily, displays chemotactic activity on resting T lymphocytes and monocytes, lower activity on neutrophils and no activity on activated T lymphocytes. The protein is also a strong suppressor of colony formation by a multipotential hematopoietic progenitor cell line. In addition, the product of this gene is a potent agonist of the chemokine (C-C motif) receptor 1. Alternative splicing results in multiple transcript variants that encode different isoforms. [provided by RefSeq, Jul 2013]
Comments
Property Summary
| NCBI Gene PubMed Count | 42 |
| Grant Count | 2 |
| Funding | $102,472.25 |
| PubMed Score | 48.75 |
| PubTator Score | 44.11 |
| Disease | Z-score | Confidence |
|---|---|---|
| interstitial cystitis 2,299 | ||
| lung adenocarcinoma 2,713 | ||
| non-small cell lung cancer 2,798 | ||
| osteosarcoma 7,933 |
| Disease | log2 FC | p |
|---|---|---|
| osteosarcoma | -3.688 | 0.000 |
| non-small cell lung cancer | -1.584 | 0.000 |
| interstitial cystitis | 1.600 | 0.000 |
| lung adenocarcinoma | -1.700 | 0.000 |
| PMID | Text |
|---|---|
| 26560043 | CCL23 is posttranslationally modified by trypsin-like serine proteases and CCL23(47-117) might be a major active form of CCL23 in nasal polyps with chronic rhinosinusitis. |
| 24995525 | The coexistence of diabetes and oxidative stress independently affected CCL23 levels, while the presence of Cardiovascular disease and inflammation had no impact on its concentrations. |
| 24384427 | ADAMTS 8, CCL23, and TNFSF15 are implicated in anti-angiogenic activities |
| 21656154 | Data show CCL23 stimulates chemotaxis of human THP-1 monocytes and enhances release of MMP-2, and suggest it plays a role in atherogenesis. |
| 21646793 | Fresh eosinophils contained trace amounts of CCL23 protein. CCL23 was significantly released into the supernatant when the eosinophils were stimulated with GM-CSF or IL-5 but not with IFN-gamma or immobilized sIgA. |
| 21497884 | Overproduction of CCL23 in nasal polyps might contribute to the pathogenesis of eosinophilic chronic rhinosinusitis with nasal polyps |
| 21109018 | The role of KLF6 and PPAR-gamma in MIP-3alpha transcriptional regulation, was determined. |
| 20824279 | Patients with systemic sclerosis who had elevated CCL23 levels had shorter disease duration, and a higher frequency of pulmonary arterial hypertension. Serum CCL23 level was increased in early phase of disease and could be a marker for disease activity. |
| 20503287 | Observational study of gene-disease association. (HuGE Navigator) |
| 20237496 | Observational study of gene-disease association. (HuGE Navigator) |
| More... |
| PMID | Year | Title |
|---|---|---|
| 26560043 | 2016 | Tissue proteases convert CCL23 into potent monocyte chemoattractants in patients with chronic rhinosinusitis. |
| 24995525 | 2014 | Effect of diabetes and oxidative stress on plasma CCL23 levels in patients with severe chronic kidney disease. |
| 24384427 | 2014 | Genome-wide study reveals an important role of spontaneous autoimmunity, cardiomyocyte differentiation defect and anti-angiogenic activities in gender-specific gene expression in Keshan disease. |
| 23932459 | 2014 | Genome-wide association study of lung function phenotypes in a founder population. |
| 22633458 | 2012 | The chemokine superfamily revisited. |
| 22147696 | 2012 | Biochemical analysis of matrix metalloproteinase activation of chemokines CCL15 and CCL23 and increased glycosaminoglycan binding of CCL16. |
| 21666788 | 2011 | Effects of chronic ascariasis and trichuriasis on cytokine production and gene expression in human blood: a cross-sectional study. |
| 21656154 | 2011 | Potential involvement of CCL23 in atherosclerotic lesion formation/progression by the enhancement of chemotaxis, adhesion molecule expression, and MMP-2 release from monocytes. |
| 21646793 | 2011 | Human eosinophils produce and release a novel chemokine, CCL23, in vitro. |
| 21497884 | 2011 | Increased expression of the chemokine CCL23 in eosinophilic chronic rhinosinusitis with nasal polyps. |
| More... |
