Tclin MTTP Microsomal triglyceride transfer protein large subunit

Protein Summary

Description

Catalyzes the transport of triglyceride, cholesteryl ester, and phospholipid between phospholipid surfaces (PubMed:23475612, PubMed:8939939, PubMed:26224785, PubMed:25108285, PubMed:22236406). Required for the secretion of plasma lipoproteins that contain apolipoprotein B (PubMed:23475612, PubMed:8939939, PubMed:26224785). MTP encodes the large subunit of the heterodimeric microsomal triglyceride transfer protein. Protein disulfide isomerase (PDI) completes the heterodimeric microsomal triglyceride transfer protein, which has been shown to play a central role in lipoprotein assembly. Mutations in MTP can cause abetalipoproteinemia. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P55157
• A8K428
• Q08AM4
• Q6P5T3

Gene Name

• MTTP

Ensembl ID

• ENST00000265517
• ENSP00000265517
• ENSG00000138823
• ENST00000422897
• ENSP00000407350
• ENST00000457717
• ENSP00000400821

Symbol

• MTP
• ABL
• MTP

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
metabolite	1
histone modification site profile	0.78
biological term	0.76
transcription factor binding site profile	0.7
cellular component	0.69

Protein Classes

PANTHER Classes

Protein / Transporter / Microsomal Triglyceride Transfer Protein Large Subunit

Protein / Transfer/carrier Protein / Apolipoprotein / Microsomal Triglyceride Transfer Protein Large Subunit

DTO Classes

Protein / Transporter / Apolipoprotein / Microsomal Triglyceride Transfer Protein Large Subunit

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 401.2   (req: < 5)

Gene RIFs: 118   (req: <= 3)

Antibodies: 229   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 401.2   (req: >= 5)

Gene RIFs: 118   (req: > 3)

Antibodies: 229   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 158

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1