Property Summary

NCBI Gene PubMed Count 234
PubMed Score 1921.32
PubTator Score 1223.42

Knowledge Summary


No data available


  Disease Sources (4)

Disease Target Count P-value
psoriasis 6685 2.01326838681957E-35
lung carcinoma 2844 4.06711245009408E-31
non-small cell lung cancer 2798 9.18005017226921E-23
lung adenocarcinoma 2714 6.24070755297298E-10
Duchenne muscular dystrophy 602 3.40962677184929E-9
posterior fossa group B ependymoma 1530 1.71572796364888E-8
lung cancer 4473 7.82183180446965E-8
sonic hedgehog group medulloblastoma 1482 1.80877246691297E-6
acute quadriplegic myopathy 1157 6.39059287308131E-6
limb girdle muscular dystrophy 2B 74 1.23079336000065E-4
atypical teratoid / rhabdoid tumor 4369 1.73614126174927E-4
medulloblastoma, large-cell 6234 2.82246752133995E-4
Down syndrome 548 4.83113038676669E-4
permanent atrial fibrillation 44 0.00162103583513969
autosomal dominant Emery-Dreifuss muscular dystrophy 499 0.002177782500514
Becker muscular dystrophy 187 0.00472750629084057
dermatomyositis 967 0.00642626090844213
pediatric high grade glioma 2712 0.0075526122631896
oligodendroglioma 2849 0.011343379642188
progressive supranuclear palsy 674 0.0203423359882213
glioblastoma 5572 0.0236135926794419
chronic rhinosinusitis 512 0.0239391883558282
pituitary cancer 1972 0.0256685072086345
gastric carcinoma 832 0.0258185845096217
primitive neuroectodermal tumor 3031 0.0453843204256724
Disease Target Count Z-score Confidence
Breast cancer 3099 0.0 2.0



Accession P55087 P78564 AQP-4
Symbols MIWC


PANTHER Protein Class (1)



  Ortholog (13)

Gene RIF (195)

26786101 Based on a comparative mutagenic analysis of AQP1, AQP 3, and AQP 4, the results suggest that loop D interactions may provide a general structural framework for tetrameric assembly within the AQP family.
26638215 Administration of E1 + P1 and E1 + P2 decreased the inhibitory effect of E1 on the IL-6 levels and AQP4 protein expression
26530185 Study shows that the processing of AQP4 by antigen presenting cells in Lewis rats produces a highly encephalitogenic AQP4 epitope (AQP4268-285)
26512424 Measurements of the membrane water permeability of MDCK cells expressing human AQP4 mutants provide the first evidencethat the rate of water flow can also be controlled by small movements of single-amino acid side chains lining the water pore.
26419740 This study demonstrated that Subcellular localization of Aqp4 was compared between cortical and white matter astrocytes in postmortem specimens of patients with focal ischemic stroke versus controls.
26287441 The induction of antibodies to an AQP4 epitope in mice immunized with the TAX1BP1-derived peptide suggests that a latent HTLV-1 infection could lead to TAX1BP1 antigen presentation and the production of anti-AQP4 antibodies in human neuromyelitis optica.
26261083 The study demonstrated the abnormal expression pattern of AQP1, AQP2, AQP3, and AQP4 in the kidney tissues of patients with nephrotic syndrome, providing a basis for an improved understanding of the role of aquaporins in the pathogenesis of this disease.
26115524 the benign subependymomas aquaporins 1 and 4 are dramatically redistributed and upregulated.
26013827 Phosphorylation at serine 276 is necessary for AQP4 translocation in response to changes of tonicity.
26000774 Study identified two AQP4 genomic variants, rs11661256 and rs1058427, as significant predictors of combined intracerebral hemorrhage and perihematomal edema volume after intracerebral hemorrhage

AA Sequence


Text Mined References (236)

PMID Year Title
26786101 2016 Structural Determinants of Oligomerization of the Aquaporin-4 Channel.
26638215 2016 Effect of estrogen and/or progesterone administration on traumatic brain injury-caused brain edema: the changes of aquaporin-4 and interleukin-6.
26530185 2015 Highly encephalitogenic aquaporin 4-specific T cells and NMO-IgG jointly orchestrate lesion location and tissue damage in the CNS.
26512424 2015 Control of the Aquaporin-4 Channel Water Permeability by Structural Dynamics of Aromatic/Arginine Selectivity Filter Residues.
26419740 2015 Heterogeneity of aquaporin-4 localization and expression after focal cerebral ischemia underlies differences in white versus grey matter swelling.
26287441 2015 Immunization of mice with a peptide derived from the HTLV-1 TAX1BP1 protein induces cross-reactive antibodies against aquaporin 4.
26261083 2015 Expression pattern of aquaporins in patients with primary nephrotic syndrome with edema.
26115524 2015 Water Channels Aquaporin 4 and -1 Expression in Subependymoma Depends on the Localization of the Tumors.
26013827 2015 Identification and Molecular Mechanisms of the Rapid Tonicity-induced Relocalization of the Aquaporin 4 Channel.
26000774 2015 Aquaporin-4 gene variant independently associated with oedema after intracerebral haemorrhage.