Property Summary

NCBI Gene PubMed Count 44
PubMed Score 291.04
PubTator Score 113.52

Knowledge Summary


No data available


  Disease Sources (2)

Disease Target Count P-value
Breast cancer 3099 4.53440106251427E-14
ependymoma 2514 7.81437942649967E-9
pediatric high grade glioma 2712 4.1646174444554E-7
atypical teratoid / rhabdoid tumor 4369 1.69926791701178E-6
pilocytic astrocytoma 3086 2.04619480433355E-5
lung cancer 4473 6.74640834463489E-5
pancreatic ductal adenocarcinoma liver metastasis 1795 5.54588282518327E-4
Down syndrome 548 6.3196099686334E-4
tuberculosis and treatment for 6 months 686 6.8440546067038E-4
ovarian cancer 8492 7.45206063048109E-4
cutaneous lupus erythematosus 1056 7.85898022381215E-4
glioblastoma 5572 0.00346580927412216
astrocytoma 1493 0.00384759625835632
Multiple myeloma 1328 0.00525051748930029
oligodendroglioma 2849 0.0266861728837984
ulcerative colitis 2087 0.0441650896857196
Disease Target Count Z-score Confidence
Inclusion conjunctivitis 8 3.273 1.6
Lymphogranuloma venereum 10 3.216 1.6


  Differential Expression (16)

Disease log2 FC p
Multiple myeloma 1.223 0.005
oligodendroglioma 1.400 0.027
cutaneous lupus erythematosus 1.500 0.001
ependymoma 1.300 0.000
glioblastoma 2.000 0.003
astrocytoma 1.300 0.004
atypical teratoid / rhabdoid tumor 1.500 0.000
ulcerative colitis -1.010 0.044
tuberculosis and treatment for 6 months -1.200 0.001
pancreatic ductal adenocarcinoma liver m... -1.407 0.001
lung cancer -1.700 0.000
pediatric high grade glioma 1.700 0.000
pilocytic astrocytoma 1.100 0.000
Breast cancer 1.300 0.000
ovarian cancer 1.400 0.001
Down syndrome 1.300 0.001


Accession P55061 B2R5M4 F8W034 O14938 Q643A7 Q96J50 BI-1
Symbols BI-1


  Ortholog (10)

Species Source
Chimp OMA EggNOG
Macaque OMA EggNOG Inparanoid
Mouse OMA EggNOG Inparanoid
Dog OMA EggNOG Inparanoid
Cow OMA EggNOG Inparanoid
Pig OMA EggNOG Inparanoid
Opossum OMA EggNOG
Anole lizard OMA EggNOG Inparanoid
Xenopus OMA EggNOG Inparanoid
Fruitfly OMA Inparanoid

Gene RIF (33)

25973025 BI-1 is overexpressed and promotes the progression and metastasis of non-small cell lung cancer
25764978 These results suggest that the TMBIM family has comparable functions in the maintenance of intracellular Ca(2) homeostasis in a wide variety of tissues
25227609 Bax inhibitor-1 is likely a pH-sensitive calcium leak channel, not a H+/Ca2+ exchanger.
24625972 Results highlight the regulatory role of BI-1 in idiopathic pulmonary fibrosis.
24344041 Constructed lentivirus expression vector for transfecting BI-1.
24314142 BI-1 enhances glucose metabolism, leading to high activation of the sodium/hydrogen exchange for intracellular pH homeostasis.
23867001 The effect of Bax Inhibitor-1(TMBIM6) as a regulatorof endoplasmic reticulum Ca2+ homeostasis is regulated by intracellular pH by removing negative charges.
22588718 The results reveal BI-1 as a novel autophagy regulator that bridges Ca(2) signaling between ER and mitochondria, reducing cellular oxygen consumption and contributing to cellular resilience in the face of metabolic stress.
22418439 Data indicate that GAAP and BI-1 have a six membrane-spanning topology with cytosolic N and C termini and a C-terminal reentrant loop.
22128171 The C terminus of Bax inhibitor-1 forms a Ca2+-permeable channel pore.

AA Sequence

FLDFITVFRKLMMILAMNEKDKKKEKK                                               211 - 237

Text Mined References (46)

PMID Year Title
25973025 2015 Bax inhibitor-1 is overexpressed in non-small cell lung cancer and promotes its progression and metastasis.
25764978 2015 The transmembrane Bax inhibitor motif (TMBIM) containing protein family: Tissue expression, intracellular localization and effects on the ER CA²?-filling state.
25227609 2014 Bax inhibitor-1 is likely a pH-sensitive calcium leak channel, not a H+/Ca2+ exchanger.
24625972 2014 BAX inhibitor-1-associated V-ATPase glycosylation enhances collagen degradation in pulmonary fibrosis.
24344041 Construction and identification of the recombinant lentiviral expression vector targeting human BAX inhibitor-1 gene.
24314142 2014 BI-1 enhances Fas-induced cell death through a Na+/H+-associated mechanism.
23867001 2013 Bax Inhibitor-1-mediated Ca2+ leak is decreased by cytosolic acidosis.
22588718 2012 Endoplasmic reticulum protein BI-1 regulates Ca²?-mediated bioenergetics to promote autophagy.
22418439 2012 Six-transmembrane topology for Golgi anti-apoptotic protein (GAAP) and Bax inhibitor 1 (BI-1) provides model for the transmembrane Bax inhibitor-containing motif (TMBIM) family.
22128171 2012 The C terminus of Bax inhibitor-1 forms a Ca2+-permeable channel pore.