Tbio APOC4 Apolipoprotein C-IV

Protein Summary

Description

May participate in lipoprotein metabolism. This gene encodes a lipid-binding protein belonging to the apolipoprotein gene family. The protein is thought to play a role in lipid metabolism. Polymorphisms in this gene may influence circulating lipid levels and may be associated with coronary artery disease risk. This gene is present in a cluster with other related apolipoprotein genes on chromosome 19. Naturally occurring read-through transcription exists between this gene and the neighboring downstream apolipoprotein C-II (APOC2) gene. [provided by RefSeq, Mar 2011]

Uniprot Accession IDs

• P55056
• B3KWY6
• Q53YY8
• Apo-CIV

Gene Name

• APOC4

Ensembl ID

• ENST00000592954
• ENSP00000468236
• ENSG00000267467

Symbol

• APO-CIV
• APOC-IV

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	1
gene perturbation	0.71
cell type or tissue	0.7
small molecule perturbation	0.58
co-expressed gene	0.52

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.55   (req: < 5)

Gene RIFs: 11   (req: <= 3)

Antibodies: 110   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.55   (req: >= 5)

Gene RIFs: 11   (req: > 3)

Antibodies: 110   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0