Tchem NR1H2 Oxysterols receptor LXR-beta

Protein Summary

Description

Nuclear receptor that exhibits a ligand-dependent transcriptional activation activity (PubMed:25661920). Binds preferentially to double-stranded oligonucleotide direct repeats having the consensus half-site sequence 5'-AGGTCA-3' and 4-nt spacing (DR-4). Regulates cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8; DLDLR and LRP8. Interplays functionally with RORA for the regulation of genes involved in liver metabolism (By similarity). Plays an anti-inflammatory role during the hepatic acute phase response by acting as a corepressor: inhibits the hepatic acute phase response by preventing dissociation of the N-Cor corepressor complex (PubMed:20159957). The liver X receptors, LXRA (NR1H3; MIM 602423) and LXRB, form a subfamily of the nuclear receptor superfamily and are key regulators of macrophage function, controlling transcriptional programs involved in lipid homeostasis and inflammation. The inducible LXRA is highly expressed in liver, adrenal gland, intestine, adipose tissue, macrophages, lung, and kidney, whereas LXRB is ubiquitously expressed. Ligand-activated LXRs form obligate heterodimers with retinoid X receptors (RXRs; see MIM 180245) and regulate expression of target genes containing LXR response elements (summary by Korf et al., 2009 [PubMed 19436111]).[supplied by OMIM, Jan 2010]

Uniprot Accession IDs

• P55055
• A8K490
• B4DNM6
• E7EWA6
• Q12970
• Q5I0Y1

Gene Name

• NR1H2

Ensembl ID

• ENST00000253727
• ENSP00000253727
• ENSG00000131408
• ENST00000411902
• ENSP00000396151
• ENST00000593926
• ENSP00000471194

Symbol

• LXRB
• NER
• UNR
• NER
• UNR
• LXRB
• LXR-b
• NER-I
• RIP15

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	1
biological process	0.99
kinase perturbation	0.88
protein domain	0.85
transcription factor binding site profile	0.67

Protein Classes

PANTHER Classes

Protein / Transcription Factor / Oxysterols Receptor Lxr-beta

Protein / Receptor / Oxysterols Receptor Lxr-beta

Protein / Nucleic Acid Binding / Oxysterols Receptor Lxr-beta

Protein / ... / C4 Zinc Finger Nuclear Receptor / Oxysterols Receptor Lxr-beta

DTO Classes

Protein / Nuclear Receptor / Liver X Receptor-like Receptors / Oxysterols Receptor Lxr-beta

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 75   (req: < 5)

Gene RIFs: 124   (req: <= 3)

Antibodies: 364   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 75   (req: >= 5)

Gene RIFs: 124   (req: > 3)

Antibodies: 364   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 45

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 358

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0