Property Summary

NCBI Gene PubMed Count 22
PubMed Score 4.68
PubTator Score 25.88

Knowledge Summary


No data available


  Disease Sources (1)

Disease Target Count P-value
posterior fossa group A ependymoma 1511 1.1736145500944E-13
breast carcinoma 1614 1.62712173802519E-10
tuberculosis 1563 3.73731241401007E-10
Breast cancer 3099 5.03223271815512E-8
malignant mesothelioma 3163 6.98676773244581E-8
primary pancreatic ductal adenocarcinoma 1271 3.04684822645087E-6
ulcerative colitis 2087 7.54481595426085E-6
lung cancer 4473 1.44658063003944E-5
pituitary cancer 1972 3.67793053959456E-5
pancreatic cancer 2300 5.18879981492578E-5
lung carcinoma 2844 1.53704658767123E-4
adrenocortical carcinoma 1427 1.96948237747573E-4
interstitial cystitis 2299 0.0011814559177514
colon cancer 1475 0.00298117627492575
glioblastoma 5572 0.00503496505004873
gastric carcinoma 832 0.00513533490699624
ovarian cancer 8492 0.00785898399854779
pediatric high grade glioma 2712 0.016443303616407
intraductal papillary-mucinous neoplasm (IPMN) 3289 0.0197823008580184
subependymal giant cell astrocytoma 2287 0.0223157570969336
atypical teratoid / rhabdoid tumor 4369 0.0234759470789059
spina bifida 1064 0.0358850273591566
intraductal papillary-mucinous adenoma (IPMA) 2956 0.0389660350539791


  Differential Expression (23)


Accession P55040 B2RA31
Symbols KIR




2CJW   2G3Y   2HT6  

  Ortholog (9)

Species Source
Chimp OMA EggNOG
Mouse OMA EggNOG Inparanoid
Rat OMA Inparanoid
Dog OMA EggNOG Inparanoid
Cow OMA EggNOG Inparanoid
Pig OMA EggNOG Inparanoid
Opossum OMA EggNOG Inparanoid
Anole lizard OMA Inparanoid
Xenopus OMA Inparanoid

Gene RIF (9)

25173885 These findings demonstrate a new role of Gem/Gmip/RhoA signaling in cortical actin regulation during early mitotic stages.
24667918 Microarray analysis indicates HIV-1 Tat-induced upregulation of GTP binding protein overexpressed in skeletal muscle (GEM) in primary human brain microvascular endothelial cells
24586148 Gem is involved both in T-cell spontaneous cell migration as well as chemotaxis and plays an important role in cell-to-cell HTLV-1 viral transmission.
22964304 Data show a mechanism by which GTPase Gem contributes to the mitotic progression by maintaining correct spindle length through the kinesin Kif9.
22589533 Gem contains two candidate inhibitory sites, each capable of producing full inhibition of P/Q-type Ca(2+) channels.
20233927 GEM plays a key role during C. pneumoniae entry into human cells.
17107948 Gem is a bona fide GTPase that exhibits striking structural and biochemical features that should impact its regulation and cellular activities
17052716 crystallographic structure and biochemical characterization indicate that Gem G-domain markedly prefers GDP over GTP
16242932 We discuss the structural and functional properties of RGK proteins and highlight recent work addressing the mechanism of Gem regulation by calmodulin and 14-3-3.

AA Sequence

MAFKLKSKSCHDLSVL                                                          281 - 296

Text Mined References (23)

PMID Year Title
25416956 2014 A proteome-scale map of the human interactome network.
25173885 2014 Gem GTPase acts upstream Gmip/RhoA to regulate cortical actin remodeling and spindle positioning during early mitosis.
24586148 2014 Gem-induced cytoskeleton remodeling increases cellular migration of HTLV-1-infected cells, formation of infected-to-target T-cell conjugates and viral transmission.
22964304 2012 The GTPase Gem and its partner Kif9 are required for chromosome alignment, spindle length control, and mitotic progression.
22589533 2012 Molecular determinants of Gem protein inhibition of P/Q-type Ca2+ channels.
20233927 2010 A systemic network for Chlamydia pneumoniae entry into human cells.
19060904 2009 An empirical framework for binary interactome mapping.
17107948 2007 Biochemical and structural characterization of the gem GTPase.
17052716 2006 Structure-function studies of the G-domain from human gem, a novel small G-protein.
16344560 2006 Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.