Tclin PDE1A Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A

Protein Summary

Description

Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. Has a higher affinity for cGMP than for cAMP. Cyclic nucleotide phosphodiesterases (PDEs) play a role in signal transduction by regulating intracellular cyclic nucleotide concentrations through hydrolysis of cAMP and/or cGMP to their respective nucleoside 5-prime monophosphates. Members of the PDE1 family, such as PDE1A, are Ca(2+)/calmodulin (see CALM1; MIM 114180)-dependent PDEs (CaM-PDEs) that are activated by calmodulin in the presence of Ca(2+) (Michibata et al., 2001 [PubMed 11342109]; Fidock et al., 2002 [PubMed 11747989]).[supplied by OMIM, Oct 2009]

Uniprot Accession IDs

• P54750
• D3DPG5
• Q86VZ0
• Q9C0K8
• Q9C0K9
• Q9C0L0
• Q9C0L1
• Q9C0L2
• Q9C0L3
• Q9C0L4
• Q9UFX3
• Cam-PDE 1A

Gene Name

• PDE1A

Ensembl ID

• ENST00000351439
• ENSP00000309269
• ENSG00000115252
• ENST00000358139
• ENSP00000350858
• ENST00000409365
• ENSP00000386767
• ENST00000410103
• ENSP00000387037
• ENST00000435564
• ENSP00000410309

Symbol

• HCAM1
• HCAM-1
• HSPDE1A
• CAM-PDE 1A
• CAM-PDE-1A

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.95
biological process	0.73
protein domain	0.73
tissue sample	0.7
ligand (protein)	0.68

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 42.42   (req: < 5)

Gene RIFs: 16   (req: <= 3)

Antibodies: 236   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 42.42   (req: >= 5)

Gene RIFs: 16   (req: > 3)

Antibodies: 236   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 17

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 3