Property Summary

NCBI Gene PubMed Count 23
Grant Count 389
R01 Count 216
Funding $69,779,299.1
PubMed Score 5982.80
PubTator Score 77.58

Knowledge Summary

Patent

No data available

TINX Plot

  Disease Relevance (51)

Disease Z-score Confidence
Gastroesophageal reflux disease 37 8.786 4.0
Peptic ulcer disease 11 7.949 4.0
Esophagitis 26 7.882 3.9
Dyspepsia 34 7.326 3.7
Barrett's esophagus 183 6.705 3.4
Hiatus hernia 7 6.682 3.3
Gastritis 44 6.585 3.3
Laryngitis 2 5.988 3.0
Zollinger-Ellison Syndrome 14 5.743 2.9
Diarrhea 155 5.31 2.7
Achalasia 11 5.059 2.5
Cancer 2,346 4.831 2.4
Bile reflux 8 4.796 2.4
Pneumonia 133 4.747 2.4
Allergic hypersensitivity disease 123 4.69 2.3
Eosinophilia 65 4.669 2.3
Duodenitis 8 4.479 2.2
Coronary artery disease 240 4.37 2.2
Dyskinesia of esophagus 3 4.37 2.2
Gastric outlet obstruction 6 4.188 2.1
Asthma 349 4.15 2.1
Irritable bowel syndrome 59 4.034 2.0
Osteoporosis 257 3.882 1.9
Constipation 43 3.873 1.9
Vitamin B12 deficiency 20 3.863 1.9
Kidney disease 396 3.838 1.9
Inflammatory bowel disease 142 3.75 1.9
Liver disease 219 3.627 1.8
Osteopetrosis 40 3.627 1.8
Anemia 252 3.599 1.8
Duodenogastric reflux 8 3.588 1.8
Gastroparesis 20 3.579 1.8
Gastric antral vascular ectasia 11 3.56 1.8
Cerebrovascular disease 231 3.537 1.8
Arthritis 248 3.41 1.7
Peritonitis 37 3.401 1.7
diabetes mellitus 1,663 3.388 1.7
X-linked myopathy with excessive autopha... 2  3.32 1.7
Hypersensitivity reaction type II diseas... 235  3.316 1.7
Pernicious anemia 10 3.31 1.7
Esophageal atresia 25 3.279 1.6
Pain disorder 13 3.203 1.6
Chronic intestinal vascular insufficienc... 12  3.151 1.6
Gastroenteritis 46 3.106 1.6
Esophageal varix 10 3.073 1.5
Varicose veins 15 3.036 1.5
Carcinoma 2,147 1.0
cutaneous lupus erythematosus 1,056
cystic fibrosis 1,665
nasopharyngeal carcinoma 1,056
psoriasis 6,685

Expression

  Differential Expression (4)

Disease log2 FC p
psoriasis 4.500 0.000
cutaneous lupus erythematosus 2.800 0.015
cystic fibrosis -1.200 0.000
nasopharyngeal carcinoma -2.400 0.000

Synonym

Accession P54707 Q13816 Q13817 Q16734 Q5W035 Q8N5U2
Symbols HK
#945
ATP1AL1

Gene

PANTHER Protein Class (2)

Gene RIF (11)

PMID Text
26823428 expressing human ATP12A in cystic fibrosis mouse airways acidified airway surface liquid, impaired defenses, and increased airway bacteria.
25366262 Genetic association studies show that carriers of ATP12A rs10507337 C allele or CCTTC haplotype had better pattern of myocardial relaxation as compared to non-carriers.
22179016 No significantly different expression levels could be detected in the various disease states compared to normal tissue.
20379614 Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
19694409 Use of fold recognition methods enables a prediction that the C-terminal domain of the beta subunits of Na,K-ATPase and H,K-ATPase has an immunoglobulin-like fold, which resembles cell adhesion molecules.
19487957 Inhibition of the ATP1AL1 isoenzyme of sodium potassium exchanging ATPase by 8-coumestrol is reported.
15135233 non-gastric H(+)/K(+)ATPase is present in the microvillous plasma membrane of the transporting epithelia of the human placenta
15086469 Carboxy-terminus of HKalpha(2) facilitates proper folding of tHKalpha(2)/beta(1) complex allowing translocation of heterodimer to plasma membrane where potassium uptake occurs. Otherwise, alpha/beta complex is destined for degradation.
12230809 Expressed in distal part of human colon and rectum, but also in proximal part of colon. Overexpressed in human colorectal adenocarcinomas adenocarcinomas. Astonishing levels of mRNA overexpression in carcinoma.
12110518 Stimulation of protein kinase C pathway mediates endocytosis of human nongastric H+-K+-ATPase, ATP1AL1.
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AA Sequence

MHQKTPEIYSVELSGTKDIVKTDKGDGKEKYRGLKNNCLELKKKNHKEEFQKELHLDDHKLSNRELEEKY      1 - 70
GTDIIMGLSSTRAAELLARDGPNSLTPPKQTPEIVKFLKQMVGGFSILLWVGAFLCWIAYGIQYSSDKSA     71 - 140
SLNNVYLGCVLGLVVILTGIFAYYQEAKSTNIMSSFNKMIPQQALVIRDSEKKTIPSEQLVVGDIVEVKG    141 - 210
GDQIPADIRVLSSQGCRVDNSSLTGESEPQPRSSEFTHENPLETKNICFYSTTCLEGTVTGMVINTGDRT    211 - 280
IIGHIASLASGVGNEKTPIAIEIEHFVHIVAGVAVSIGILFFIIAVSLKYQVLDSIIFLIGIIVANVPEG    281 - 350
LLATVTVTLSLTAKRMAKKNCLVKNLEAVETLGSTSIICSDKTGTLTQNRMTVAHLWFDNQIFVADTSED    351 - 420
HSNQVFDQSSRTWASLSKIITLCNRAEFKPGQENVPIMKKAVIGDASETALLKFSEVILGDVMEIRKRNR    421 - 490
KVAEIPFNSTNKFQLSIHEMDDPHGKRFLMVMKGAPERILEKCSTIMINGEEHPLDKSTAKTFHTAYMEL    491 - 560
GGLGERVLGFCHLYLPADEFPETYSFDIDAMNFPTSNLCFVGLLSMIDPPRSTVPDAVTKCRSAGIKVIM    561 - 630
VTGDHPITAKAIAKSVGIISANSETVEDIAHRLNIAVEQVNKRDAKAAVVTGMELKDMSSEQLDEILANY    631 - 700
QEIVFARTSPQQKLIIVEGCQRQDAVVAVTGDGVNDSPALKKADIGIAMGIAGSDAAKNAADMVLLDDNF    701 - 770
ASIVTGVEEGRLIFDNLKKTIAYSLTKNIAELCPFLIYIIVGLPLPIGTITILFIDLGTDIIPSIALAYE    771 - 840
KAESDIMNRKPRHKNKDRLVNQPLAVYSYLHIGLMQALGAFLVYFTVYAQEGFLPRTLINLRVEWEKDYV    841 - 910
NDLKDSYGQEWTRYQREYLEWTGYTAFFVGILVQQIADLIIRKTRRNSIFQQGLFRNKVIWVGITSQIII    911 - 980
GLILSYGLGSVTALSFTMLRAQYWFVAVPHAILIWVYDEVRKLFIRLYPGSWWDKNMYY               981 - 1039
//

Text Mined References (27)

PMID Year Title
26823428 2016 Airway acidification initiates host defense abnormalities in cystic fibrosis mice.
25366262 2014 Left ventricular diastolic function associated with common genetic variation in ATP12A in a general population.
25322912 2014 The putative role of the non-gastric H?/K?-ATPase ATP12A (ATP1AL1) as anti-apoptotic ion transporter: effect of the H?/K? ATPase inhibitor SCH28080 on butyrate-stimulated myelomonocytic HL-60 cells.
24275569 2014 An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
23251661 2012 Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
22179016 2011 Expression of the non-gastric H+/K+ ATPase ATP12A in normal and pathological human prostate tissue.
20379614 Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
19694409 2009 A C-terminal lobe of the beta subunit of Na,K-ATPase and H,K-ATPase resembles cell adhesion molecules.
19487957 2009 Inhibition of the alpha1beta1 isoform of the Na, K-ATPase by 8-methoxycoumestrol without positive inotropic effect in human myocardium--novel aspects of cardiac glycoside pharmacology.
16344560 2006 Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.
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