Property Summary

NCBI Gene PubMed Count 23
PubMed Score 5982.80
PubTator Score 77.58

Knowledge Summary

Patent

No data available

TINX Plot

  Disease Sources (3)

Disease Target Count P-value
nasopharyngeal carcinoma 1056 9.59215681871415E-11
psoriasis 6685 7.65056617048369E-5
cystic fibrosis 1670 1.43815447272103E-4
cutaneous lupus erythematosus 1056 0.0152567552194265
Disease Target Count Z-score Confidence
Carcinoma 2147 0.0 1.0

Expression

  Differential Expression (4)

Disease log2 FC p
psoriasis 4.500 0.000
cutaneous lupus erythematosus 2.800 0.015
cystic fibrosis -1.200 0.000
nasopharyngeal carcinoma -2.400 0.000

Synonym

Accession P54707 Q13816 Q13817 Q16734 Q5W035 Q8N5U2
Symbols HK
#945
ATP1AL1

Gene

PANTHER Protein Class (2)

  Ortholog (12)

Gene RIF (11)

PMID Text
26823428 expressing human ATP12A in cystic fibrosis mouse airways acidified airway surface liquid, impaired defenses, and increased airway bacteria.
25366262 Genetic association studies show that carriers of ATP12A rs10507337 C allele or CCTTC haplotype had better pattern of myocardial relaxation as compared to non-carriers.
22179016 No significantly different expression levels could be detected in the various disease states compared to normal tissue.
20379614 Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
19694409 Use of fold recognition methods enables a prediction that the C-terminal domain of the beta subunits of Na,K-ATPase and H,K-ATPase has an immunoglobulin-like fold, which resembles cell adhesion molecules.
19487957 Inhibition of the ATP1AL1 isoenzyme of sodium potassium exchanging ATPase by 8-coumestrol is reported.
15135233 non-gastric H(+)/K(+)ATPase is present in the microvillous plasma membrane of the transporting epithelia of the human placenta
15086469 Carboxy-terminus of HKalpha(2) facilitates proper folding of tHKalpha(2)/beta(1) complex allowing translocation of heterodimer to plasma membrane where potassium uptake occurs. Otherwise, alpha/beta complex is destined for degradation.
12230809 Expressed in distal part of human colon and rectum, but also in proximal part of colon. Overexpressed in human colorectal adenocarcinomas adenocarcinomas. Astonishing levels of mRNA overexpression in carcinoma.
12110518 Stimulation of protein kinase C pathway mediates endocytosis of human nongastric H+-K+-ATPase, ATP1AL1.
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AA Sequence

MHQKTPEIYSVELSGTKDIVKTDKGDGKEKYRGLKNNCLELKKKNHKEEFQKELHLDDHKLSNRELEEKY      1 - 70
GTDIIMGLSSTRAAELLARDGPNSLTPPKQTPEIVKFLKQMVGGFSILLWVGAFLCWIAYGIQYSSDKSA     71 - 140
SLNNVYLGCVLGLVVILTGIFAYYQEAKSTNIMSSFNKMIPQQALVIRDSEKKTIPSEQLVVGDIVEVKG    141 - 210
GDQIPADIRVLSSQGCRVDNSSLTGESEPQPRSSEFTHENPLETKNICFYSTTCLEGTVTGMVINTGDRT    211 - 280
IIGHIASLASGVGNEKTPIAIEIEHFVHIVAGVAVSIGILFFIIAVSLKYQVLDSIIFLIGIIVANVPEG    281 - 350
LLATVTVTLSLTAKRMAKKNCLVKNLEAVETLGSTSIICSDKTGTLTQNRMTVAHLWFDNQIFVADTSED    351 - 420
HSNQVFDQSSRTWASLSKIITLCNRAEFKPGQENVPIMKKAVIGDASETALLKFSEVILGDVMEIRKRNR    421 - 490
KVAEIPFNSTNKFQLSIHEMDDPHGKRFLMVMKGAPERILEKCSTIMINGEEHPLDKSTAKTFHTAYMEL    491 - 560
GGLGERVLGFCHLYLPADEFPETYSFDIDAMNFPTSNLCFVGLLSMIDPPRSTVPDAVTKCRSAGIKVIM    561 - 630
VTGDHPITAKAIAKSVGIISANSETVEDIAHRLNIAVEQVNKRDAKAAVVTGMELKDMSSEQLDEILANY    631 - 700
QEIVFARTSPQQKLIIVEGCQRQDAVVAVTGDGVNDSPALKKADIGIAMGIAGSDAAKNAADMVLLDDNF    701 - 770
ASIVTGVEEGRLIFDNLKKTIAYSLTKNIAELCPFLIYIIVGLPLPIGTITILFIDLGTDIIPSIALAYE    771 - 840
KAESDIMNRKPRHKNKDRLVNQPLAVYSYLHIGLMQALGAFLVYFTVYAQEGFLPRTLINLRVEWEKDYV    841 - 910
NDLKDSYGQEWTRYQREYLEWTGYTAFFVGILVQQIADLIIRKTRRNSIFQQGLFRNKVIWVGITSQIII    911 - 980
GLILSYGLGSVTALSFTMLRAQYWFVAVPHAILIWVYDEVRKLFIRLYPGSWWDKNMYY               981 - 1039
//

Text Mined References (27)

PMID Year Title
26823428 2016 Airway acidification initiates host defense abnormalities in cystic fibrosis mice.
25366262 2014 Left ventricular diastolic function associated with common genetic variation in ATP12A in a general population.
25322912 2014 The putative role of the non-gastric H?/K?-ATPase ATP12A (ATP1AL1) as anti-apoptotic ion transporter: effect of the H?/K? ATPase inhibitor SCH28080 on butyrate-stimulated myelomonocytic HL-60 cells.
24275569 2014 An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
23251661 2012 Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
22179016 2011 Expression of the non-gastric H+/K+ ATPase ATP12A in normal and pathological human prostate tissue.
20379614 Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
19694409 2009 A C-terminal lobe of the beta subunit of Na,K-ATPase and H,K-ATPase resembles cell adhesion molecules.
19487957 2009 Inhibition of the alpha1beta1 isoform of the Na, K-ATPase by 8-methoxycoumestrol without positive inotropic effect in human myocardium--novel aspects of cardiac glycoside pharmacology.
16344560 2006 Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.
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