Property Summary

NCBI Gene PubMed Count 18
PubMed Score 0.00
PubTator Score 33.55

Knowledge Summary

Patent

No data available

Synonym

Accession P54317 A8K627 Q6IB55 PL-RP2
Symbols PLRP2

Gene

PANTHER Protein Class (3)

PDB

2OXE   2PVS  

Gene RIF (11)

PMID Text
26494624 The beta5-Loop and Lid Domain Contribute to the Substrate Specificity of Pancreatic Lipase-related Protein 2
23732775 Pancreatic lipase-related protein 2 digests fats in human milk and formula in concert with gastric lipase and carboxyl ester lipase.
21865348 BSSL and PLRP2 hydrolyzed triglycerides (TG) to free FA and glycerol.
21652702 Pancreatic lipase-related protein-2 (PLRP2) can contribute to dietary fat digestion in human newborns
21554982 localization of PLRP2 in endosomes of monocytes
19548271 The pancreatic lipase related protein 2 is required for lipid-dependent cytotoxicity mediated by cytotoxic T lymphocytes.
18702514 Most of the structural and kinetic properties of HPLRP2 were found to be different from those of rat PLRP2
17401110 finding that the inhibition of nonproteolyzed rHPLRP2 by tetrahydrolipstatin and diethyl-p-nitrophenyl phosphate does not involve any bile salt requirements suggests that the rHPLRP2 lid adopts an open conformation in aqueous media.
16887271 Patients with chronic calcifying pancreatitis (CCP) had significantly lower levels of both pancreatic lipase and PLRP2 than the controls subjects.
16385451 Observational study of gene-disease association. (HuGE Navigator)
More...

AA Sequence

MLPPWTLGLLLLATVRGKEVCYGQLGCFSDEKPWAGTLQRPVKLLPWSPEDIDTRFLLYTNENPNNFQLI      1 - 70
TGTEPDTIEASNFQLDRKTRFIIHGFLDKAEDSWPSDMCKKMFEVEKVNCICVDWRHGSRAMYTQAVQNI     71 - 140
RVVGAETAFLIQALSTQLGYSLEDVHVIGHSLGAHTAAEAGRRLGGRVGRITGLDPAGPCFQDEPEEVRL    141 - 210
DPSDAVFVDVIHTDSSPIVPSLGFGMSQKVGHLDFFPNGGKEMPGCKKNVLSTITDIDGIWEGIGGFVSC    211 - 280
NHLRSFEYYSSSVLNPDGFLGYPCASYDEFQESKCFPCPAEGCPKMGHYADQFKGKTSAVEQTFFLNTGE    281 - 350
SGNFTSWRYKVSVTLSGKEKVNGYIRIALYGSNENSKQYEIFKGSLKPDASHTCAIDVDFNVGKIQKVKF    351 - 420
LWNKRGINLSEPKLGASQITVQSGEDGTEYNFCSSDTVEENVLQSLYPC                         421 - 469
//

Text Mined References (21)

PMID Year Title
26494624 2015 The ?5-Loop and Lid Domain Contribute to the Substrate Specificity of Pancreatic Lipase-related Protein 2 (PNLIPRP2).
23732775 2013 Pancreatic lipase-related protein 2 digests fats in human milk and formula in concert with gastric lipase and carboxyl ester lipase.
22359512 2012 Genome-wide association study identifies novel loci associated with circulating phospho- and sphingolipid concentrations.
21865348 2011 BSSL and PLRP2: key enzymes for lipid digestion in the newborn examined using the Caco-2 cell line.
21652702 2011 Pancreatic lipase-related protein-2 (PLRP2) can contribute to dietary fat digestion in human newborns.
21554982 Bis (monoacylglycero) phosphate interfacial properties and lipolysis by pancreatic lipase-related protein 2, an enzyme present in THP-1 human monocytes.
20445095 2010 Colloquium paper: human adaptations to diet, subsistence, and ecoregion are due to subtle shifts in allele frequency.
20083229 2010 Lipolysis of natural long chain and synthetic medium chain galactolipids by pancreatic lipase-related protein 2.
19824014 2009 Individual and combined action of pancreatic lipase and pancreatic lipase-related proteins 1 and 2 on native versus homogenized milk fat globules.
19548271 2009 Lipid-dependent cytotoxicity by the lipase PLRP2 and by PLRP2-positive cytotoxic T lymphocytes (CTLs).
More...