PMS1
PMS1 protein homolog 1
Protein Summary
Probably involved in the repair of mismatches in DNA. This gene encodes a protein belonging to the DNA mismatch repair mutL/hexB family. This protein is thought to be involved in the repair of DNA mismatches, and it can form heterodimers with MLH1, a known DNA mismatch repair protein. Mutations in this gene cause hereditary nonpolyposis colorectal cancer type 3 (HNPCC3) either alone or in combination with mutations in other genes involved in the HNPCC phenotype, which is also known as Lynch syndrome. [provided by RefSeq, Jul 2008]
- ENST00000409593
- ENSP00000387169
- ENSG00000064933
- ENST00000409823
- ENSP00000387125
- ENST00000441310
- ENSP00000406490
- ENST00000447232
- ENSP00000401064
- PMSL1
- MLH2
- PMSL1
- hPMS1
- HNPCC3
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
molecular function | 0.96 | ||
protein domain | 0.92 | ||
histone modification site profile | 0.89 | ||
transcription factor binding site profile | 0.72 | ||
hub protein | 0.67 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 259.61 (req: < 5)
Gene RIFs: 18 (req: <= 3)
Antibodies: 309 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 259.61 (req: >= 5)
Gene RIFs: 18 (req: > 3)
Antibodies: 309 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 7
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0