Tbio SUB1 Activated RNA polymerase II transcriptional coactivator p15

Protein Summary

Description

General coactivator that functions cooperatively with TAFs and mediates functional interactions between upstream activators and the general transcriptional machinery. May be involved in stabilizing the multiprotein transcription complex. Binds single-stranded DNA. Also binds, in vitro, non-specifically to double-stranded DNA (ds DNA).

Uniprot Accession IDs

• P53999
• Q96L29

Gene Name

• SUB1

Ensembl ID

• ENST00000265073
• ENSP00000265073
• ENSG00000113387
• ENST00000502897
• ENSP00000427100
• ENST00000506237
• ENSP00000422078
• ENST00000512913
• ENSP00000422806
• ENST00000515355
• ENSP00000426850

Symbol

• PC4
• RPO2TC1
• P15
• PC4
• p14

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
virus perturbation	0.97
kinase perturbation	0.96
transcription factor perturbation	0.96
transcription factor binding site profile	0.84
disease perturbation	0.79

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 430.96   (req: < 5)

Gene RIFs: 36   (req: <= 3)

Antibodies: 241   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 430.96   (req: >= 5)

Gene RIFs: 36   (req: > 3)

Antibodies: 241   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0