Tchem SLC16A1 Monocarboxylate transporter 1

Protein Summary

Description

Proton-coupled monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate. Depending on the tissue and on cicumstances, mediates the import or export of lactic acid and ketone bodies. Required for normal nutrient assimilation, increase of white adipose tissue and body weight gain when on a high-fat diet. Plays a role in cellular responses to a high-fat diet by modulating the cellular levels of lactate and pyruvate, small molecules that contribute to the regulation of central metabolic pathways and insulin secretion, with concomitant effects on plasma insulin levels and blood glucose homeostasis. The protein encoded by this gene is a proton-linked monocarboxylate transporter that catalyzes the movement of many monocarboxylates, such as lactate and pyruvate, across the plasma membrane. Mutations in this gene are associated with erythrocyte lactate transporter defect. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Oct 2009]

Uniprot Accession IDs

• P53985
• Q49A45
• Q5T8R6
• Q9NSJ9
• MCT 1

Gene Name

• SLC16A1

Ensembl ID

• ENST00000369626
• ENSP00000358640
• ENSG00000155380
• ENST00000538576
• ENSP00000441065
• ENST00000628110
• ENSP00000485688
• ENSG00000281917
• ENST00000630362
• ENSP00000486000

Symbol

• MCT1
• MCT
• HHF7
• MCT1
• MCT1D

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
drug perturbation	1
transcription factor binding site profile	0.92
kinase perturbation	0.91
drug	0.89
histone modification site profile	0.86

Protein Classes

PANTHER Classes

Protein / Transporter / Monocarboxylate Transporter 1

DTO Classes

Protein / Transporter / Slc Superfamily Of Solute Carriers / Slc16 Family Of Monocarboxylate Transporters / Monocarboxylate Transporter 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 391   (req: < 5)

Gene RIFs: 164   (req: <= 3)

Antibodies: 285   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 391   (req: >= 5)

Gene RIFs: 164   (req: > 3)

Antibodies: 285   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 18

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 65

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0