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Tchem
SLC16A1
Monocarboxylate transporter 1

Protein Summary
Description
Proton-coupled monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate. Depending on the tissue and on cicumstances, mediates the import or export of lactic acid and ketone bodies. Required for normal nutrient assimilation, increase of white adipose tissue and body weight gain when on a high-fat diet. Plays a role in cellular responses to a high-fat diet by modulating the cellular levels of lactate and pyruvate, small molecules that contribute to the regulation of central metabolic pathways and insulin secretion, with concomitant effects on plasma insulin levels and blood glucose homeostasis. The protein encoded by this gene is a proton-linked monocarboxylate transporter that catalyzes the movement of many monocarboxylates, such as lactate and pyruvate, across the plas ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000369626
  • ENSP00000358640
  • ENSG00000155380
  • ENST00000538576
  • ENSP00000441065
  • ENST00000628110
  • ENSP00000485688
  • ENSG00000281917
  • ENST00000630362
  • ENSP00000486000

Symbol
  • MCT1
  • MCT
  • HHF7
  • MCT1
  • MCT1D
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
drug perturbation
1
transcription factor binding site profile
0.92
kinase perturbation
0.91
drug
0.89
histone modification site profile
0.86


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 391   (req: < 5)
Gene RIFs: 164   (req: <= 3)
Antibodies: 285   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 391   (req: >= 5)
Gene RIFs: 164   (req: > 3)
Antibodies: 285   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 18
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 65
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0