Property Summary

NCBI Gene PubMed Count 94
PubMed Score 242.01
PubTator Score 173.07

Knowledge Summary


No data available


  Disease Sources (4)

Disease Target Count P-value
breast carcinoma 1614 2.00895403546561E-25
Breast cancer 3099 1.50833507646575E-17
non-small cell lung cancer 2798 2.28316176549881E-8
medulloblastoma, large-cell 6234 1.47863021292814E-7
malignant mesothelioma 3163 1.84935887815389E-6
juvenile dermatomyositis 1189 3.32922959110543E-6
pituitary cancer 1972 1.0318085231877E-5
lung adenocarcinoma 2714 1.37212067327157E-5
psoriasis 6685 1.74641700054853E-5
lung cancer 4473 4.08657006466453E-5
interstitial cystitis 2299 6.29988462235491E-5
ovarian cancer 8492 7.62468465229449E-5
tuberculosis 1563 1.75926868571517E-4
sonic hedgehog group medulloblastoma 1482 3.83647637276665E-4
pancreatic ductal adenocarcinoma liver metastasis 1795 5.54588282518327E-4
cystic fibrosis 1670 0.00173958810270674
intraductal papillary-mucinous carcinoma (IPMC) 2988 0.00225709676416893
intraductal papillary-mucinous adenoma (IPMA) 2956 0.00346779948626809
glioblastoma 5572 0.00833668712876832
invasive ductal carcinoma 2950 0.0111146980469034
dermatomyositis 967 0.0124423786028473
intraductal papillary-mucinous neoplasm (IPMN) 3289 0.0212092646889975
Disease Target Count Z-score Confidence
Rheumatoid Arthritis 1171 0.0 5.0



Accession P53805 D3DSF9 O00582 O00583 Q53XT0 Q6IBC6 Q7Z555 Q96R03 Q9BU69 Q9UF15 Q9UME4
Symbols CSP1


PANTHER Protein Class (1)

  Ortholog (13)

Gene RIF (77)

26569438 The objective of this study was aimed to detect the association of Down syndrome critical region 1 (DSCR1) gene polymorphisms (rs149048873 and rs143081213) and congenital heart disease (CHD) susceptibility.
26497675 Results support overexpression of RCAN1 and particularly the RCAN1.1S isoform during aging as a pathogenic mechanism in both Down syndrome-related and sporadic Alzheimer's disease
26492364 RCAN1 can interact with IkappaBalpha and affect the phosphorylation of IkappaBalpha at tyrosine 42.
26102033 E4BP4 and BIM regulation correlated with that of RCAN1-1. A putative GRE and four EBPREs were identified within 1500bp upstream from the transcription start site of RCAN1-1
25978972 Rcan1-1L may play a protective role in Ang II-treated cardiomyocytes through the induction of mitochondrial autophagy, and may be an alternative method of cardiac protection.
25863471 The sequence variations in RCAN1 promoter are not major genetic factors involved in sporadic CHD, at least in the current research population.
25753203 results suggest the presence of a novel phosphorylation site in RCAN1 and that its phosphorylation influences calcineurin-dependent inflammatory target gene expression
25546086 These results suggest that USP22 positively regulates RCAN1 levels, which would consequently affect diverse RCAN1-linked cellular processes.
25379721 For DSCR1rs6517239, patients with an AA genotype had higher recurrence probability than patients carrying at least one allele G (37 +/- 4% SE vs. 15 +/- 6% SE) (HR: 0.51; 95% CI, 0.27-0.94; P = 0.027).
25377251 Results show that Rcan1 isoform 1L (Rcan1-1L) overexpression specifically activates mitophagy and increases cell survival under hypoxic conditions.

AA Sequence


Text Mined References (94)

PMID Year Title
26569438 2015 Association Between DSCR1 Variations and Congenital Heart Disease Susceptibility.
26497675 2015 RCAN1 overexpression promotes age-dependent mitochondrial dysregulation related to neurodegeneration in Alzheimer's disease.
26492364 2015 The RCAN1 inhibits NF-?B and suppresses lymphoma growth in mice.
26157140 2015 Pituitary Adenylate Cyclase-activating Polypeptide (PACAP) Targets Down Syndrome Candidate Region 1 (DSCR1/RCAN1) to control Neuronal Differentiation.
26102033 2015 Glucocorticoid-mediated co-regulation of RCAN1-1, E4BP4 and BIM in human leukemia cells susceptible to apoptosis.
25978972 2015 Rcan1-1L overexpression induces mitochondrial autophagy and improves cell survival in angiotensin II-exposed cardiomyocytes.
25863471 2015 Association Between Sequence Variations in RCAN1 Promoter and the Risk of Sporadic Congenital Heart Disease in a Chinese Population.
25753203 2015 PKA regulates calcineurin function through the phosphorylation of RCAN1: identification of a novel phosphorylation site.
25546086 2015 Ubiquitin-specific protease 22 (USP22) positively regulates RCAN1 protein levels through RCAN1 de-ubiquitination.
25379721 2015 Genetic variants within obesity-related genes are associated with tumor recurrence in patients with stages II/III colon cancer.