Tchem MAPK10 Mitogen-activated protein kinase 10

Protein Summary

Description

Serine/threonine-protein kinase involved in various processes such as neuronal proliferation, differentiation, migration and programmed cell death. Extracellular stimuli such as proinflammatory cytokines or physical stress stimulate the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. In this cascade, two dual specificity kinases MAP2K4/MKK4 and MAP2K7/MKK7 phosphorylate and activate MAPK10/JNK3. In turn, MAPK10/JNK3 phosphorylates a number of transcription factors, primarily components of AP-1 such as JUN and ATF2 and thus regulates AP-1 transcriptional activity. Plays regulatory roles in the signaling pathways during neuronal apoptosis. Phosphorylates the neuronal microtubule regulator STMN2. Acts in the regulation of the amyloid-beta precursor protein/APP signaling during neuronal differentiation by phosphorylating APP. Participates also in neurite growth in spiral ganglion neurons. Phosphorylates the CLOCK-ARNTL/BMAL1 heterodimer and plays a role in the photic regulation of the circadian clock (PubMed:22441692). The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as integration points for multiple biochemical signals, and thus are involved in a wide variety of cellular processes, such as proliferation, differentiation, transcription regulation and development. This kinase is specifically expressed in a subset of neurons in the nervous system, and is activated by threonine and tyrosine phosphorylation. Targeted deletion of this gene in mice suggests that it may have a role in stress-induced neuronal apoptosis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. A recent study provided evidence for translational readthrough in this gene, and expression of an additional C-terminally extended isoform via the use of an alternative in-frame translation termination codon. [provided by RefSeq, Dec 2017]

Uniprot Accession IDs

• P53779
• A6NFS3
• A6NG28
• B3KQ94
• Q15707
• Q49AP1
• MAP kinase 10

Gene Name

• MAPK10

Ensembl ID

• ENST00000395157
• ENSP00000378586
• ENSG00000109339
• ENST00000395166
• ENSP00000378595
• ENST00000515400
• ENSP00000424154
• ENST00000515650
• ENSP00000492204
• ENST00000638225
• ENSP00000491866
• ENST00000638313
• ENSP00000492292
• ENST00000639175
• ENSP00000491160
• ENST00000639234
• ENSP00000491306
• ENST00000639242
• ENSP00000491089
• ENST00000640858
• ENSP00000491122
• ENST00000640970
• ENSP00000492231
• ENST00000641050
• ENSP00000493270
• ENST00000641051
• ENSP00000493275
• ENST00000641066
• ENSP00000493072
• ENST00000641110
• ENSP00000493163
• ENST00000641157
• ENSP00000493363
• ENST00000641170
• ENSP00000493237
• ENST00000641207
• ENSP00000493450
• ENST00000641274
• ENSP00000492929
• ENST00000641283
• ENSP00000493444
• ENST00000641287
• ENSP00000493100
• ENST00000641297
• ENSP00000493092
• ENST00000641341
• ENSP00000493290
• ENST00000641391
• ENSP00000493008
• ENST00000641410
• ENSP00000493208
• ENST00000641462
• ENSP00000493435
• ENST00000641647
• ENSP00000493375
• ENST00000641657
• ENSP00000493105
• ENST00000641724
• ENSP00000493038
• ENST00000641737
• ENSP00000493177
• ENST00000641803
• ENSP00000493049
• ENST00000641823
• ENSP00000493408
• ENST00000641862
• ENSP00000493396
• ENST00000641902
• ENSP00000492903
• ENST00000641911
• ENSP00000493374
• ENST00000641943
• ENSP00000492941
• ENST00000641952
• ENSP00000493013
• ENST00000641983
• ENSP00000493045
• ENST00000642009
• ENSP00000493168
• ENST00000642015
• ENSP00000493040
• ENST00000642038
• ENSP00000492942
• ENST00000642103
• ENSP00000493001

Symbol

• JNK3
• JNK3A
• PRKM10
• SAPK1B
• JNK3
• JNK3A
• PRKM10
• SAPK1b
• p493F12
• p54bSAPK

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
hub protein	0.99
molecular function	0.99
virus perturbation	0.96
biological process	0.88
pathway	0.85

Protein Classes

PANTHER Classes

Protein / Transferase / Kinase / Protein Kinase / Non-receptor Serine/threonine Protein Kinase / Mitogen-activated Protein Kinase 10

DTO Classes

Protein / Kinase / Protein Kinase / Cmgc Group / Mapk Family / Jnk Subfamily / Mitogen-activated Protein Kinase 10

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 285.91   (req: < 5)

Gene RIFs: 33   (req: <= 3)

Antibodies: 485   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 285.91   (req: >= 5)

Gene RIFs: 33   (req: > 3)

Antibodies: 485   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 208

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0