Property Summary

NCBI Gene PubMed Count 29
Grant Count 1
Funding $64,125
PubMed Score 19.33
PubTator Score 17.05

Knowledge Summary

Patent

No data available

Expression

  Differential Expression (14)

Disease log2 FC p
nephrosclerosis 1.032 0.000
osteosarcoma -1.960 0.021
non diabetic and post-ischemic heart fai... 1.100 0.009
adrenocortical carcinoma -1.672 0.001
non-small cell lung cancer -2.856 0.000
intraductal papillary-mucinous neoplasm ... -1.200 0.004
lung cancer -3.800 0.000
interstitial cystitis -1.200 0.002
lung adenocarcinoma -1.900 0.000
lung carcinoma -2.800 0.000
Pick disease 1.400 0.000
pituitary cancer -1.400 0.001
head and neck cancer -1.900 0.019
psoriasis -1.100 0.000

Synonym

Accession P53708 B0YJ31 Q5VX94
Symbols

Gene

 Grant Application (1)

 GO Function (1)

Gene RIF (16)

PMID Text
24700879 In 15 of 590 families, we identified recessive mutations in the genes FRAS1, FREM2, GRIP1, FREM1, ITGA8, and GREM1, all of which function in the interaction of the ureteric bud and the metanephric mesenchyme.
24667918 Microarray analysis indicates HIV-1 Tat-induced upregulation of integrin, alpha 8 (ITGA8) in primary human brain microvascular endothelial cells
24439109 Mutations of ITGA8 are a genetic cause of bilateral renal agenesis and that, at least in some cases, bilateral renal agenesis is an autosomal-recessive disease.
23153507 the ITGA8 gene might have gender-specific roles in the development of schizophrenia.
23142384 Analysis of the data demonstrated that Itga8 expression is CArG box-serum response factor independent, but myocardin dependent through an as yet unknown sequence module that is distal from the promoter region.
20942236 The mRNA levels of Integrinalpha8 were significantly lower in LSCC tissues than that in corresponding adjacent normal tissues.
20678483 alpha8beta1 is a prerequisite for the proper conduct of anoikis in normal human intestinal epithelial crypt cells, whereas its loss contributes to the illicit acquisition of anoikis resistance.
19527220 In intestinal crypt cells, integrin alpha8beta1 is closely involved in the regulation of adhesion, migration and cell proliferation via a predominant RhoA/ROCK-dependent mechanism.
19342381 These results indicate that the specific high-affinity binding of nephronectin to alpha8beta1 integrin is achieved by bipartite interaction of the integrin with the RGD motif and LFEIFEIER sequence.
18277079 A polymorphism of the ITGA8 promoter modifies the progression of renal failure in ADPKD.
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AA Sequence

MSPGASRGPRGSQAPLIAPLCCAAAALGMLLWSPACQAFNLDVEKLTVYSGPKGSYFGYAVDFHIPDART      1 - 70
ASVLVGAPKANTSQPDIVEGGAVYYCPWPAEGSAQCRQIPFDTTNNRKIRVNGTKEPIEFKSNQWFGATV     71 - 140
KAHKGKVVACAPLYHWRTLKPTPEKDPVGTCYVAIQNFSAYAEFSPCRNSNADPEGQGYCQAGFSLDFYK    141 - 210
NGDLIVGGPGSFYWQGQVITASVADIIANYSFKDILRKLAGEKQTEVAPASYDDSYLGYSVAAGEFTGDS    211 - 280
QQELVAGIPRGAQNFGYVSIINSTDMTFIQNFTGEQMASYFGYTVVVSDVNSDGLDDVLVGAPLFMEREF    281 - 350
ESNPREVGQIYLYLQVSSLLFRDPQILTGTETFGRFGSAMAHLGDLNQDGYNDIAIGVPFAGKDQRGKVL    351 - 420
IYNGNKDGLNTKPSQVLQGVWASHAVPSGFGFTLRGDSDIDKNDYPDLIVGAFGTGKVAVYRARPVVTVD    421 - 490
AQLLLHPMIINLENKTCQVPDSMTSAACFSLRVCASVTGQSIANTIVLMAEVQLDSLKQKGAIKRTLFLD    491 - 560
NHQAHRVFPLVIKRQKSHQCQDFIVYLRDETEFRDKLSPINISLNYSLDESTFKEGLEVKPILNYYRENI    561 - 630
VSEQAHILVDCGEDNLCVPDLKLSARPDKHQVIIGDENHLMLIINARNEGEGAYEAELFVMIPEEADYVG    631 - 700
IERNNKGFRPLSCEYKMENVTRMVVCDLGNPMVSGTNYSLGLRFAVPRLEKTNMSINFDLQIRSSNKDNP    701 - 770
DSNFVSLQINITAVAQVEIRGVSHPPQIVLPIHNWEPEEEPHKEEEVGPLVEHIYELHNIGPSTISDTIL    771 - 840
EVGWPFSARDEFLLYIFHIQTLGPLQCQPNPNINPQDIKPAASPEDTPELSAFLRNSTIPHLVRKRDVHV    841 - 910
VEFHRQSPAKILNCTNIECLQISCAVGRLEGGESAVLKVRSRLWAHTFLQRKNDPYALASLVSFEVKKMP    911 - 980
YTDQPAKLPEGSIVIKTSVIWATPNVSFSIPLWVIILAILLGLLVLAILTLALWKCGFFDRARPPQEDMT    981 - 1050
DREQLTNDKTPEA                                                            1051 - 1063
//

Text Mined References (29)

PMID Year Title
24700879 2014 Mild recessive mutations in six Fraser syndrome-related genes cause isolated congenital anomalies of the kidney and urinary tract.
24439109 2014 Integrin alpha 8 recessive mutations are responsible for bilateral renal agenesis in humans.
24024966 2013 Genome-wide association study of chronic periodontitis in a general German population.
23154389 2013 Regulation of endodermal differentiation of human embryonic stem cells through integrin-ECM interactions.
23153507 2013 A missense mutation in the ITGA8 gene, a cell adhesion molecule gene, is associated with schizophrenia in Japanese female patients.
23142384 2013 Expression and promoter analysis of a highly restricted integrin alpha gene in vascular smooth muscle.
21423176 2011 Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for ?-Pix in negative regulation of focal adhesion maturation.
21335239 2011 The basement membrane of hair follicle stem cells is a muscle cell niche.
20942236 2010 [Expression and significance of integrins subunits in laryngeal squamous cell carcinoma].
20678483 2010 Integrin alpha8beta1 confers anoikis susceptibility to human intestinal epithelial crypt cells.
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