Tchem LIMK2 LIM domain kinase 2

Protein Summary

Description

Displays serine/threonine-specific phosphorylation of myelin basic protein and histone (MBP) in vitro. There are approximately 40 known eukaryotic LIM proteins, so named for the LIM domains they contain. LIM domains are highly conserved cysteine-rich structures containing 2 zinc fingers. Although zinc fingers usually function by binding to DNA or RNA, the LIM motif probably mediates protein-protein interactions. LIM kinase-1 and LIM kinase-2 belong to a small subfamily with a unique combination of 2 N-terminal LIM motifs and a C-terminal protein kinase domain. The protein encoded by this gene is phosphorylated and activated by ROCK, a downstream effector of Rho, and the encoded protein, in turn, phosphorylates cofilin, inhibiting its actin-depolymerizing activity. It is thought that this pathway contributes to Rho-induced reorganization of the actin cytoskeleton. At least three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P53671
• A8K6H5
• Q7KZ80
• Q7L3H5
• Q96E10
• Q99464
• Q9UFU0
• LIMK-2

Gene Name

• LIMK2

Ensembl ID

• ENST00000331728
• ENSP00000332687
• ENSG00000182541
• ENST00000333611
• ENSP00000330470
• ENST00000340552
• ENSP00000339916

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.97
transcription factor perturbation	0.96
kinase perturbation	0.91
transcription factor	0.91
transcription factor binding site profile	0.86

Protein Classes

DTO Classes

Protein / Kinase / Protein Kinase / Tkl Group / Lisk Family / Limk Subfamily / Lim Domain Kinase 2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 66.94   (req: < 5)

Gene RIFs: 40   (req: <= 3)

Antibodies: 525   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 66.94   (req: >= 5)

Gene RIFs: 40   (req: > 3)

Antibodies: 525   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 103

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0