Property Summary

NCBI Gene PubMed Count 46
PubMed Score 39.00
PubTator Score 40.05

Knowledge Summary

Patent (7,267)

TINX Plot

  Disease Sources (2)

Disease Target Count P-value
glioblastoma multiforme 347 1.14157235103823E-10
ovarian cancer 8492 1.38624130463119E-7
posterior fossa group A ependymoma 1511 3.72773588032405E-7
malignant mesothelioma 3163 3.02686438256117E-6
osteosarcoma 7933 6.15574600787574E-6
psoriasis 6685 1.04890367265655E-4
intraductal papillary-mucinous adenoma (IPMA) 2956 6.78016378134572E-4
pilocytic astrocytoma 3086 0.00144214590219163
intraductal papillary-mucinous carcinoma (IPMC) 2988 0.00519530171535603
lung cancer 4473 0.00909535281946826
subependymal giant cell astrocytoma 2287 0.0205175148149553
axial spondyloarthropathy 28 0.0411582751312336
Disease Target Count Z-score Confidence
Kidney disease 397 0.0 1.0
diabetes mellitus 1663 0.0 1.0

Expression

Synonym

Gene

PDB

1X6A   4TPT  

  Ortholog (13)

Species Source
Chimp OMA EggNOG
Macaque OMA EggNOG
Mouse OMA EggNOG Inparanoid
Rat OMA EggNOG Inparanoid
Dog OMA Inparanoid
Horse OMA Inparanoid
Cow OMA Inparanoid
Pig OMA Inparanoid
Opossum OMA Inparanoid
Platypus OMA Inparanoid
Chicken OMA Inparanoid
Xenopus OMA Inparanoid
Zebrafish OMA Inparanoid

  TechDev Info (1)

Gary Johnson Kinome profile via MIB/MS Technology

MLP Assay (1)

AID Type Active / Inconclusive / Inactive Description
1982 other 0 / 0 / 0 Kinase inhibition selectivity assay for compound SID-48409448

Gene RIF (26)

PMID Text
25981171 This study showed that LIMK2 messenger RNA levels was significantly upregulated in subjects with schizophrenia in laminar and cellular samples.
25849865 Actin remodelling factor LIMK2 is a key player in the ciliogenesis control network in which YAP/TAZ and directional vesicle trafficking are integral components.
25344584 Results show that in addition to a potential role in promoting metastasis, changes in LIMK1 and LIMK2 expression and/or activity might contribute to AR function in prostate cancer via regulation of microtubule cytoskeletal dynamics.
23991158 results highlight the exciting possibility of combining specific LIMK2 inhibitors with anticancer drugs in the treatment of multi-drug resistant cancers
23585469 LIMK2 expression was reduced in intestinal tumours of cancer-prone mice and in human colorectal cancer cell lines and tumours. LIMK2 expression progressively decreased with advancing stage of colorectal cancer.
23239465 Overexpression of LIMK2 is associated with breast cancer growth and invasiveness.
23082153 Nf1/LIMK2 interaction and inhibition allows to directly connect neurofibromatosis type I to actin cytoskeleton remodeling.
22883572 A novel activity of Rho in promoting a complex between fascin-1 and LIMK1/2 that modulates the interaction of fascin-1 with actin, was identified.
22492986 LIMK2 positively regulates the level of Aurora A, thereby engaging in a positive-feedback loop, promoting Aurora-A-mediated oncogenic pathways.
22328514 LIMK2 is a key regulator that acts through different substrates to provide functional links between the actin cytoskeleton and spindle dynamics.
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AA Sequence

MSALAGEDVWRCPGCGDHIAPSQIWYRTVNETWHGSCFRCSECQDSLTNWYYEKDGKLYCPKDYWGKFGE      1 - 70
FCHGCSLLMTGPFMVAGEFKYHPECFACMSCKVIIEDGDAYALVQHATLYCGKCHNEVVLAPMFERLSTE     71 - 140
SVQEQLPYSVTLISMPATTEGRRGFSVSVESACSNYATTVQVKEVNRMHISPNNRNAIHPGDRILEINGT    141 - 210
PVRTLRVEEVEDAISQTSQTLQLLIEHDPVSQRLDQLRLEARLAPHMQNAGHPHALSTLDTKENLEGTLR    211 - 280
RRSLRRSNSISKSPGPSSPKEPLLFSRDISRSESLRCSSSYSQQIFRPCDLIHGEVLGKGFFGQAIKVTH    281 - 350
KATGKVMVMKELIRCDEETQKTFLTEVKVMRSLDHPNVLKFIGVLYKDKKLNLLTEYIEGGTLKDFLRSM    351 - 420
DPFPWQQKVRFAKGIASGMAYLHSMCIIHRDLNSHNCLIKLDKTVVVADFGLSRLIVEERKRAPMEKATT    421 - 490
KKRTLRKNDRKKRYTVVGNPYWMAPEMLNGKSYDETVDIFSFGIVLCEIIGQVYADPDCLPRTLDFGLNV    491 - 560
KLFWEKFVPTDCPPAFFPLAAICCRLEPESRPAFSKLEDSFEALSLYLGELGIPLPAELEELDHTVSMQY    561 - 630
GLTRDSPP                                                                  631 - 638
//

Text Mined References (53)

PMID Year Title
25981171 2015 Altered expression of CDC42 signaling pathway components in cortical layer 3 pyramidal cells in schizophrenia.
25849865 2015 Actin remodelling factors control ciliogenesis by regulating YAP/TAZ activity and vesicle trafficking.
25344584 2015 Elevated LIM kinase 1 in nonmetastatic prostate cancer reflects its role in facilitating androgen receptor nuclear translocation.
23991158 2013 LIMK2 mediates resistance to chemotherapeutic drugs in neuroblastoma cells through regulation of drug-induced cell cycle arrest.
23776197 2013 Genome-wide association study identifies ephrin type A receptors implicated in paclitaxel induced peripheral sensory neuropathy.
23585469 2014 Reduced LIMK2 expression in colorectal cancer reflects its role in limiting stem cell proliferation.
23239465 2013 LIM kinase inhibition reduces breast cancer growth and invasiveness but systemic inhibition does not reduce metastasis in mice.
23186163 2013 Toward a comprehensive characterization of a human cancer cell phosphoproteome.
23082153 2012 Nf1 RasGAP inhibition of LIMK2 mediates a new cross-talk between Ras and Rho pathways.
22939624 2012 Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition.
More...