Tchem METAP1 Methionine aminopeptidase 1

Protein Summary

Description

Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Required for normal progression through the cell cycle.

Uniprot Accession IDs

• P53582
• B4E2E6
• MAP 1

Gene Name

• METAP1

Ensembl ID

• ENST00000296411
• ENSP00000296411
• ENSG00000164024

Symbol

• KIAA0094
• MAP1A
• MetAP1A

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
co-expressed gene	1
disease perturbation	0.98
kinase perturbation	0.95
virus perturbation	0.92
histone modification site profile	0.8

Protein Classes

PANTHER Classes

Protein / Transcription Factor / Methionine Aminopeptidase 1

Protein / Nucleic Acid Binding / Methionine Aminopeptidase 1

Protein / Hydrolase / Protease / Metalloprotease / Methionine Aminopeptidase 1

DTO Classes

Protein / Enzyme / Protease / Metalloprotease / Methionine Aminopeptidase 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 59.23   (req: < 5)

Gene RIFs: 10   (req: <= 3)

Antibodies: 190   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 59.23   (req: >= 5)

Gene RIFs: 10   (req: > 3)

Antibodies: 190   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 73

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0