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Tbio
HMGA2
High mobility group protein HMGI-C

Protein Summary
Description
Functions as a transcriptional regulator. Functions in cell cycle regulation through CCNA2. Plays an important role in chromosome condensation during the meiotic G2/M transition of spermatocytes. Plays a role in postnatal myogenesis, is involved in satellite cell activation (By similarity). This gene encodes a protein that belongs to the non-histone chromosomal high mobility group (HMG) protein family. HMG proteins function as architectural factors and are essential components of the enhancesome. This protein contains structural DNA-binding domains and may act as a transcriptional regulating factor. Identification of the deletion, amplification, and rearrangement of this gene that are associated with myxoid liposarcoma suggests a role in adipogenesis and mesenchymal differentiation. A gene knock out study of the mouse counterpart demonstrated that this gene is involved in diet-induced obesity. Alternate transcriptional splice variants, encoding different isoforms, have been characteriz ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000354636
  • ENSP00000346658
  • ENSG00000149948
  • ENST00000393578
  • ENSP00000377206
  • ENST00000403681
  • ENSP00000384026
  • ENST00000425208
  • ENSP00000407306
  • ENST00000537275
  • ENSP00000437747
  • ENST00000537429
  • ENSP00000443372

Symbol
  • HMGIC
  • BABL
  • LIPO
  • HMGIC
  • HMGI-C
  • STQTL9
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
molecular function
1
transcription factor perturbation
1
PubMedID
0.99
microRNA
0.95


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1199.82   (req: < 5)
Gene RIFs: 413   (req: <= 3)
Antibodies: 263   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1199.82   (req: >= 5)
Gene RIFs: 413   (req: > 3)
Antibodies: 263   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 66
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0