Tchem AKR1C2 Aldo-keto reductase family 1 member C2

Protein Summary

Description

Works in concert with the 5-alpha/5-beta-steroid reductases to convert steroid hormones into the 3-alpha/5-alpha and 3-alpha/5-beta-tetrahydrosteroids. Catalyzes the inactivation of the most potent androgen 5-alpha-dihydrotestosterone (5-alpha-DHT) to 5-alpha-androstane-3-alpha,17-beta-diol (3-alpha-diol). Has a high bile-binding ability. This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols using NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme binds bile acid with high affinity, and shows minimal 3-alpha-hydroxysteroid dehydrogenase activity. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]

Uniprot Accession IDs

• P52895
• A8K2N9
• B4DKR9
• Q14133
• Q5SR16
• Q7M4N1
• Q96A71

Gene Name

• AKR1C2

Ensembl ID

• ENST00000380753
• ENSP00000370129
• ENSG00000151632
• ENST00000455190
• ENSP00000408440

Symbol

• DDH2
• DD
• DD2
• TDD
• BABP
• DD-2
• DDH2
• HBAB
• HAKRD
• MCDR2
• SRXY8
• DD/BABP
• AKR1C-pseudo

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
small molecule perturbation	0.94
molecular function	0.91
chemical	0.9
biological process	0.71
transcription factor perturbation	0.68

Protein Classes

PANTHER Classes

Protein / Oxidoreductase / Reductase / Aldo-keto Reductase Family 1 Member C2

DTO Classes

Protein / Enzyme / Oxidoreductase / Reductase / Aldo-keto Reductase Family 1 Member C2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 958.86   (req: < 5)

Gene RIFs: 50   (req: <= 3)

Antibodies: 264   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 958.86   (req: >= 5)

Gene RIFs: 50   (req: > 3)

Antibodies: 264   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 23

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 49

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2