Property Summary

NCBI Gene PubMed Count 24
PubMed Score 79.33
PubTator Score 34.02

Knowledge Summary

Patent

No data available

TINX Plot

  Disease Sources (5)

Disease Target Count P-value
lung adenocarcinoma 2714 4.75171303050056E-20
lung carcinoma 2844 5.24759514982333E-12
malignant mesothelioma 3163 2.46310992621524E-7
medulloblastoma, large-cell 6234 6.08084235467929E-5
psoriasis 6685 9.91666469980132E-5
Disease Target Count Z-score Confidence
Intellectual disability 573 0.0 4.0
Disease Target Count Z-score Confidence
Goldenhar syndrome 19 3.114 1.6

Expression

  Differential Expression (5)

Disease log2 FC p
malignant mesothelioma 1.600 0.000
psoriasis -1.700 0.000
medulloblastoma, large-cell -1.500 0.000
lung adenocarcinoma -1.200 0.000
lung carcinoma -1.300 0.000

Synonym

Accession P52848 Q96E57
Symbols HSST
NST1
MRT46

Gene

PDB

1NST  

  Ortholog (9)

Species Source
Chimp OMA EggNOG
Macaque OMA EggNOG Inparanoid
Mouse OMA EggNOG Inparanoid
Rat OMA EggNOG Inparanoid
Cow OMA EggNOG Inparanoid
Opossum EggNOG Inparanoid
Platypus OMA EggNOG Inparanoid
Chicken OMA Inparanoid
Xenopus OMA Inparanoid

Gene RIF (13)

PMID Text
26109066 demonstrate the essential role of domain cooperation within NDST-1 in producing HS with specific domain structures
25156775 Upregulation of NDST1 is associated with chemoresistance in breast cancer.
25125150 Our data confirm NDST1 mutations as a cause of autosomal recessive intellectual disability with a distinctive phenotype, and support an important function of NDST1 in human development.
23884416 These findings establish NDST1 as a target of miR-24 and demonstrate how such NDST1 suppression in endothelial cells results in reduced responsiveness to VEGFA
22632162 FITC-labeled Tat 47-59 peptide downregulates gene expression of N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1 (NDST1) in U-937 macrophages
21947487 MicroRNA-191 targets N-deacetylase/N-sulfotransferase 1 and promotes cell growth in human gastric carcinoma cell line MGC803
20198315 Observational study of gene-disease association. (HuGE Navigator)
20129923 Inhibitory peptides of the sulfotransferase domain of the heparan sulfate enzyme, N-deacetylase-N-sulfotransferase-1.
19915053 the expression of the NDST-1 isoform was approximately equal at all stages of mast cell maturation
19851296 Observational study of gene-disease association. (HuGE Navigator)
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AA Sequence

MPALACLRRLCRHVSPQAVLFLLFIFCLFSVFISAYYLYGWKRGLEPSADAPEPDCGDPPPVAPSRLLPL      1 - 70
KPVQAATPSRTDPLVLVFVESLYSQLGQEVVAILESSRFKYRTEIAPGKGDMPTLTDKGRGRFALIIYEN     71 - 140
ILKYVNLDAWNRELLDKYCVAYGVGIIGFFKANENSLLSAQLKGFPLFLHSNLGLKDCSINPKSPLLYVT    141 - 210
RPSEVEKGVLPGEDWTVFQSNHSTYEPVLLAKTRSSESIPHLGADAGLHAALHATVVQDLGLHDGIQRVL    211 - 280
FGNNLNFWLHKLVFVDAVAFLTGKRLSLPLDRYILVDIDDIFVGKEGTRMKVEDVKALFDTQNELRAHIP    281 - 350
NFTFNLGYSGKFFHTGTNAEDAGDDLLLSYVKEFWWFPHMWSHMQPHLFHNQSVLAEQMALNKKFAVEHG    351 - 420
IPTDMGYAVAPHHSGVYPVHVQLYEAWKQVWSIRVTSTEEYPHLKPARYRRGFIHNGIMVLPRQTCGLFT    421 - 490
HTIFYNEYPGGSSELDKIINGGELFLTVLLNPISIFMTHLSNYGNDRLGLYTFKHLVRFLHSWTNLRLQT    491 - 560
LPPVQLAQKYFQIFSEEKDPLWQDPCEDKRHKDIWSKEKTCDRFPKLLIIGPQKTGTTALYLFLGMHPDL    561 - 630
SSNYPSSETFEEIQFFNGHNYHKGIDWYMEFFPIPSNTTSDFYFEKSANYFDSEVAPRRAAALLPKAKVL    631 - 700
TILINPADRAYSWYQHQRAHDDPVALKYTFHEVITAGSDASSKLRALQNRCLVPGWYATHIERWLSAYHA    701 - 770
NQILVLDGKLLRTEPAKVMDMVQKFLGVTNTIDYHKTLAFDPKKGFWCQLLEGGKTKCLGKSKGRKYPEM    771 - 840
DLDSRAFLKDYYRDHNIELSKLLYKMGQTLPTWLREDLQNTR                                841 - 882
//

Text Mined References (25)

PMID Year Title
26109066 2015 Role of Deacetylase Activity of N-Deacetylase/N-Sulfotransferase 1 in Forming N-Sulfated Domain in Heparan Sulfate.
25156775 2014 Methylation-regulated miR-149 modulates chemoresistance by targeting GlcNAc N-deacetylase/N-sulfotransferase-1 in human breast cancer.
25125150 2014 NDST1 missense mutations in autosomal recessive intellectual disability.
23884416 2013 MicroRNA-24 suppression of N-deacetylase/N-sulfotransferase-1 (NDST1) reduces endothelial cell responsiveness to vascular endothelial growth factor A (VEGFA).
22660413 2012 Syndecan-syntenin-ALIX regulates the biogenesis of exosomes.
21947487 2011 MicroRNA-191 targets N-deacetylase/N-sulfotransferase 1 and promotes cell growth in human gastric carcinoma cell line MGC803.
20198315 2010 Association of genetic variants with hemorrhagic stroke in Japanese individuals.
20129923 2011 Inhibitory peptides of the sulfotransferase domain of the heparan sulfate enzyme, N-deacetylase-N-sulfotransferase-1.
19915053 2009 Mast cell differentiation and activation is closely linked to expression of genes coding for the serglycin proteoglycan core protein and a distinct set of chondroitin sulfate and heparin sulfotransferases.
19851296 2010 Assessment of a polymorphism of SDK1 with hypertension in Japanese Individuals.
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