Property Summary

NCBI Gene PubMed Count 104
Grant Count 244
R01 Count 121
Funding $30,071,851.16
PubMed Score 268.00
PubTator Score 192.09

Knowledge Summary

Patent

No data available

Expression

Synonym

Accession P52799 Q5JV56
Symbols HTKL
EPLG5
Htk-L
LERK5

Gene

PDB

2WO2   3GXU   2HLE   2I85   2VSK   2VSM   4UF7  

Gene RIF (72)

PMID Text
26754526 Results suggest a potential signalling hierarchy between Delta-like 1 and ephrin-B2 ligands, as neural stem cells adopt the Delta-like 1 phenotype of stem cell maintenance on simultaneous presentation of both signals.
26277777 Together, these findings suggest that CCL2, RARRES2 and EFNB2 are host cell factors involved in respiratory syncytial virus replication.
26212082 increased notably in preeclampsia endothelial progenitor cells and placenta
25825759 Molecular recognition of human ephrinB2 cell surface receptor by an emergent African henipavirus.
25807892 EfnB2 is an essential regulator of endothelial cell death and vessel pruning. This regulation depends upon phosphotyrosine-EfnB2 signaling repressing JNK3 activity via STAT1.
25748802 role in maternal spiral artery remodeling in first trimester
25724897 Human ephrin-B2 is poorly cleaved by KLK4 while the homologous mouse is not.
25434750 Results suggest that ephrinB2 may function as a colorectal cancer cells growth stimulator.
24634162 These genes may be potential biomarkers for identification of subclinical lymph node involvement in papillary thyroid carcinoma (PTC)
24615845 Data suggest that fusion of Nipah viruses with host cells is facilitated by two of viral membrane proteins, the G protein and the F protein; G head domain binds to human ephrins B2 and B3 altering conformational density of entire G head domain.
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AA Sequence

MAVRRDSVWKYCWGVLMVLCRTAISKSIVLEPIYWNSSNSKFLPGQGLVLYPQIGDKLDIICPKVDSKTV      1 - 70
GQYEYYKVYMVDKDQADRCTIKKENTPLLNCAKPDQDIKFTIKFQEFSPNLWGLEFQKNKDYYIISTSNG     71 - 140
SLEGLDNQEGGVCQTRAMKILMKVGQDASSAGSTRNKDPTRRPELEAGTNGRSSTTSPFVKPNPGSSTDG    141 - 210
NSAGHSGNNILGSEVALFAGIASGCIIFIVIIITLVVLLLKYRRRHRKHSPQHTTTLSLSTLATPKRSGN    211 - 280
NNGSEPSDIIIPLRTADSVFCPHYEKVSGDYGHPVYIVQEMPPQSPANIYYKV                     281 - 333
//

Text Mined References (108)

PMID Year Title
26754526 2016 Interrogating cellular fate decisions with high-throughput arrays of multiplexed cellular communities.
26277777 2015 Identification of CCL2, RARRES2 and EFNB2 as host cell factors that influence the multistep replication of respiratory syncytial virus.
26268439 2015 p75(NTR)-dependent activation of NF-?B regulates microRNA-503 transcription and pericyte-endothelial crosstalk in diabetes after limb ischaemia.
26212082 2015 The role of Delta-like 4 ligand/Notch-ephrin-B2 cascade in the pathogenesis of preeclampsia by regulating functions of endothelial progenitor cell.
25825759 2015 Molecular recognition of human ephrinB2 cell surface receptor by an emergent African henipavirus.
25807892 2015 EphrinB2 controls vessel pruning through STAT1-JNK3 signalling.
25748802 2015 Ephrin-B2 mediates trophoblast-dependent maternal spiral artery remodeling in first trimester.
25724897 2015 Murine, but not human, ephrin-B2 can be efficiently cleaved by the serine protease kallikrein-4: implications for xenograft models of human prostate cancer.
25434750 2015 Effects of ephrinB2 gene siRNA on the biological behavior of human colorectal cancer cells.
24634162 2015 Overexpression of EphB4, EphrinB2, and epidermal growth factor receptor in papillary thyroid carcinoma: A pilot study.
More...