Tbio EFNA4 Ephrin-A4

Protein Summary

Description

Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. May play a role in the interaction between activated B-lymphocytes and dendritic cells in tonsils. This gene encodes a member of the ephrin (EPH) family. The ephrins and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, especially in the nervous system and in erythropoiesis. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. This gene encodes an EFNA class ephrin. Three transcript variants that encode distinct proteins have been identified. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P52798
• C9JHJ8
• G3XAK2
• O95457
• Q5SR71
• Q6FI57

Gene Name

• EFNA4

Ensembl ID

• ENST00000359751
• ENSP00000352789
• ENSG00000243364
• ENST00000368409
• ENSP00000357394
• ENST00000427683
• ENSP00000414378

Symbol

• EPLG4
• LERK4
• EFL4
• EPLG4
• LERK4

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.85
transcription factor binding site profile	0.74
molecular function	0.73
disease perturbation	0.68
gene perturbation	0.63

Protein Classes

PANTHER Classes

Protein / Signaling Molecule / Membrane-bound Signaling Molecule / Ephrin-a4

DTO Classes

Protein / Signaling / Membrane-bound Signaling Molecule / Ephrin-a4

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 28.29   (req: < 5)

Gene RIFs: 11   (req: <= 3)

Antibodies: 273   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 28.29   (req: >= 5)

Gene RIFs: 11   (req: > 3)

Antibodies: 273   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0