Tchem HK2 Hexokinase-2

Protein Summary

Description

Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. This gene encodes hexokinase 2, the predominant form found in skeletal muscle. It localizes to the outer membrane of mitochondria. Expression of this gene is insulin-responsive, and studies in rat suggest that it is involved in the increased rate of glycolysis seen in rapidly growing cancer cells. [provided by RefSeq, Apr 2009]

Uniprot Accession IDs

• P52789
• D6W5J2
• Q8WU87
• Q9UN82

Gene Name

• HK2

Ensembl ID

• ENST00000290573
• ENSP00000290573
• ENSG00000159399

Symbol

• HKII
• HXK2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.97
PubMedID	0.82
gene perturbation	0.8
interacting protein	0.8
microRNA	0.8

Protein Classes

DTO Classes

Protein / Kinase / Unclassified Protein / Hexokinase-2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 864.65   (req: < 5)

Gene RIFs: 210   (req: <= 3)

Antibodies: 630   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 864.65   (req: >= 5)

Gene RIFs: 210   (req: > 3)

Antibodies: 630   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 21

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 5

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0