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Tbio
SLC7A2
Cationic amino acid transporter 2

Protein Summary
Description
Functions as permease involved in the transport of the cationic amino acids (arginine, lysine and ornithine); the affinity for its substrates differs between isoforms created by alternative splicing. Isoform 1 functions as permease that mediates the transport of the cationic amino acids (arginine, lysine and ornithine), and it has much higher affinity for arginine than isoform 2. Isoform 2 functions as low-affinity, high capacity permease involved in the transport of the cationic amino acids (arginine, lysine and ornithine) (PubMed:9174363). May play a role in classical or alternative activation of macrophages via its role in arginine transport. The protein encoded by this gene is a cationic amino acid transporter and a member of the APC (amino acid-polyamine-organocation) family of transporters. The encoded membrane protein is responsible for the cellular uptake of arginine, lysine and ornithine. Three transcript variants encoding different isoforms have been found for this gene. [pro ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000004531
  • ENSP00000004531
  • ENSG00000003989
  • ENST00000398090
  • ENSP00000381164
  • ENST00000470360
  • ENSP00000419873
  • ENST00000494857
  • ENSP00000419140
  • ENST00000522656
  • ENSP00000430464

Symbol
  • ATRC2
  • CAT2
  • CAT2
  • ATRC2
  • HCAT2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.96
transcription factor perturbation
0.94
molecular function
0.81
microRNA
0.8
biological process
0.69


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 51.57   (req: < 5)
Gene RIFs: 17   (req: <= 3)
Antibodies: 101   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 51.57   (req: >= 5)
Gene RIFs: 17   (req: > 3)
Antibodies: 101   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0