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Tbio
RAP1GDS1
Rap1 GTPase-GDP dissociation stimulator 1

Protein Summary
Description
Stimulates GDP/GTP exchange reaction of a group of small GTP-binding proteins (G proteins) including Rap1a/Rap1b, RhoA, RhoB and KRas, by stimulating the dissociation of GDP from and the subsequent binding of GTP to each small G protein. The smg GDP dissociation stimulator (smgGDS) protein is a stimulatory GDP/GTP exchange protein with GTPase activity (Riess et al., 1993 [PubMed 8262526]).[supplied by OMIM, Feb 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000264572
  • ENSP00000264572
  • ENSG00000138698
  • ENST00000339360
  • ENSP00000340454
  • ENST00000380158
  • ENSP00000369503
  • ENST00000408900
  • ENSP00000386223
  • ENST00000408927
  • ENSP00000386153
  • ENST00000453712
  • ENSP00000407157

Symbol
  • GDS1
  • SmgGDS
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.93
kinase perturbation
0.93
transcription factor perturbation
0.91
histone modification site profile
0.9
interacting protein
0.86


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 31.04   (req: < 5)
Gene RIFs: 29   (req: <= 3)
Antibodies: 142   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 31.04   (req: >= 5)
Gene RIFs: 29   (req: > 3)
Antibodies: 142   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0