Property Summary

NCBI Gene PubMed Count 69
PubMed Score 125.70
PubTator Score 125.18

Knowledge Summary


No data available


  Disease Sources (3)

Disease Target Count
HIV Infections 100
Disease Target Count P-value
ovarian cancer 8492 3.37061844275929E-8
atypical teratoid / rhabdoid tumor 4369 8.71400063968108E-8
medulloblastoma 1524 2.80760536761884E-6
medulloblastoma, large-cell 6234 1.2952122722035E-5
Breast cancer 3099 1.93094127955316E-5
lung cancer 4473 1.81443384731672E-4
primitive neuroectodermal tumor 3031 3.48635576326945E-4
invasive ductal carcinoma 2950 7.93495601204583E-4
glioblastoma 5572 0.00122881388585243
osteosarcoma 7933 0.00205556773204727
colon cancer 1475 0.0123798053330597
Disease Target Count Z-score Confidence
Cancer 2346 3.781 1.9


  Differential Expression (11)

Disease log2 FC p
osteosarcoma -1.384 0.002
atypical teratoid / rhabdoid tumor 1.400 0.000
glioblastoma 1.100 0.001
medulloblastoma 1.100 0.000
medulloblastoma, large-cell 1.800 0.000
primitive neuroectodermal tumor 1.100 0.000
lung cancer 1.500 0.000
colon cancer 1.100 0.012
invasive ductal carcinoma 1.200 0.001
ovarian cancer 2.600 0.000
Breast cancer 1.200 0.000


Accession P51858 B3KU21 D3DVC9 Q5SZ07 Q5SZ08 Q5SZ09 HDGF
Symbols HMG1L2



1RI0   2NLU  

  Ortholog (7)

Species Source
Chimp OMA EggNOG
Mouse OMA EggNOG Inparanoid
Rat OMA Inparanoid
Dog OMA Inparanoid
Cow OMA Inparanoid
Opossum OMA Inparanoid
Xenopus OMA EggNOG Inparanoid

Gene RIF (55)

26845719 describe two previously unknown HDGF isoforms, HDGF-B and HDGF-C, generated via alternative splicing with structurally unrelated N-terminal regions of their hath region
26612514 study uncovers a novel function of HDGF as a messenger of cellular condition (alarmin) which in-turn modulates cellular function-aspects that could be used as a biomarker for ovarian cancer.
26296979 HDGF and beta-catenin interact as a positive feedback loop, which plays an important role in carcinogenesis and progression of colorectal carcinoma.
26081074 HDGF is important in promoting malignant biological behaviors, including proliferation, migration and invasion of hilar cholangiocarcinoma cells.
26067205 HDGF contains conserved N-terminal HATH domains with a characteristic structural motif, namely the PWWP motif. This study defines the role of the first residue of the PWWP motif in modulating HATH domain stability and oligomer formation in binding.
25938538 Hepatoma-derived growth factor overexpression is involved in liver carcinogenesis.
25773828 Meta-analysis results provide evidence that HDGF may be a new indicator of poor cancer prognosis.
25677618 These data suggested that irradiated fibroblasts promoted invasion, growth, EMT and HDGF expression of ESCC.
25421244 HDGF overexpression is common in early-stage cervical adenocarcinoma.
25275311 The expression level of hepatoma-derived growth factor (HDGF) significantly decreased in response to the virus-associated RNAs under replication-deficient condition.

AA Sequence

PQEEEEEEDEEEEATKEDAEAPGIRDHESL                                            211 - 240

Text Mined References (92)

PMID Year Title
26845719 2016 Two new isoforms of the human hepatoma-derived growth factor interact with components of the cytoskeleton.
26612514 2016 Hepatoma derived growth factor (HDGF) dynamics in ovarian cancer cells.
26296979 2015 Positive feedback loop of hepatoma-derived growth factor and ?-catenin promotes carcinogenesis of colorectal cancer.
26081074 2015 Downregulation of the expression of HDGF attenuates malignant biological behaviors of hilar cholangiocarcinoma cells.
26067205 2015 The First Residue of the PWWP Motif Modulates HATH Domain Binding, Stability, and Protein-Protein Interaction.
25938538 2015 Hepatoma-derived growth factor/nucleolin axis as a novel oncogenic pathway in liver carcinogenesis.
25773828 2015 Prognostic role of hepatoma-derived growth factor in solid tumors of Eastern Asia: a systematic review and meta- analysis.
25772364 2015 SUMO-2 Orchestrates Chromatin Modifiers in Response to DNA Damage.
25677618 2015 Irradiated fibroblasts promote epithelial-mesenchymal transition and HDGF expression of esophageal squamous cell carcinoma.
25421244 2014 Hepatoma-derived growth factor upregulation is correlated with prognostic factors of early-stage cervical adenocarcinoma.