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Tbio
AFF2
AF4/FMR2 family member 2

Protein Summary
Description
RNA-binding protein. Might be involved in alternative splicing regulation through an interaction with G-quartet RNA structure. This gene encodes a putative transcriptional activator that is a member of the AF4\FMR2 gene family. This gene is associated with the folate-sensitive fragile X E locus on chromosome X. A repeat polymorphism in the fragile X E locus results in silencing of this gene causing Fragile X E syndrome. Fragile X E syndrome is a form of nonsyndromic X-linked cognitive disability. In addition, this gene contains 6-25 GCC repeats that are expanded to >200 repeats in the disease state. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Jul 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000286437
  • ENSP00000286437
  • ENSG00000155966
  • ENST00000342251
  • ENSP00000345459
  • ENST00000370457
  • ENSP00000359486
  • ENST00000370458
  • ENSP00000359487
  • ENST00000370460
  • ENSP00000359489

Symbol
  • FMR2
  • OX19
  • FMR2
  • MRX2
  • OX19
  • FMR2P
  • FRAXE
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
0.97
trait
0.93
microRNA
0.92
tissue
0.62
tissue sample
0.62


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 357.83   (req: < 5)
Gene RIFs: 18   (req: <= 3)
Antibodies: 145   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 357.83   (req: >= 5)
Gene RIFs: 18   (req: > 3)
Antibodies: 145   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0