Tclin CCR5 C-C chemokine receptor type 5

Protein Summary

Description

Receptor for a number of inflammatory CC-chemokines including CCL3/MIP-1-alpha, CCL4/MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation. (Microbial infection) Acts as a coreceptor (CD4 being the primary receptor) of human immunodeficiency virus-1/HIV-1. This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. This protein is expressed by T cells and macrophages, and is known to be an important co-receptor for macrophage-tropic virus, including HIV, to enter host cells. Defective alleles of this gene have been associated with the HIV infection resistance. The ligands of this receptor include monocyte chemoattractant protein 2 (MCP-2), macrophage inflammatory protein 1 alpha (MIP-1 alpha), macrophage inflammatory protein 1 beta (MIP-1 beta) and regulated on activation normal T expressed and secreted protein (RANTES). Expression of this gene was also detected in a promyeloblastic cell line, suggesting that this protein may play a role in granulocyte lineage proliferation and differentiation. This gene is located at the chemokine receptor gene cluster region. An allelic polymorphism in this gene results in both functional and non-functional alleles; the reference genome represents the functional allele. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2015]

Uniprot Accession IDs

• P51681
• O14692
• O14693
• O14695
• O14696
• O14697
• O14698
• O14699
• O14700
• O14701
• O14702
• O14703
• O14704
• O14705
• O14706
• O14707
• O14708
• O15538
• Q9UPA4
• C-C CKR-5

Gene Name

• CCR5

Ensembl ID

• ENST00000292303
• ENSP00000292303
• ENSG00000160791
• ENST00000445772
• ENSP00000404881

Symbol

• CMKBR5
• CKR5
• CCR-5
• CD195
• CKR-5
• CCCKR5
• CMKBR5
• IDDM22
• CC-CKR-5

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
ligand (protein)	1
molecular function	0.94
PubMedID	0.94
biological process	0.84
biological term	0.8

Protein Classes

DTO Classes

Protein / G-protein Coupled Receptor / Class A Rhodopsin Like / Chemokine Receptor / C-c Chemokine Receptor / C-c Chemokine Receptor Type 5

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5040.6   (req: < 5)

Gene RIFs: 786   (req: <= 3)

Antibodies: 1618   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5040.6   (req: >= 5)

Gene RIFs: 786   (req: > 3)

Antibodies: 1618   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 30

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 1426

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1