Property Summary

NCBI Gene PubMed Count 37
PubMed Score 120.80
PubTator Score 112.55

Knowledge Summary

Patent

No data available

TINX Plot

  Disease Sources (3)

Disease Target Count
non-small cell lung carcinoma 413
Disease Target Count P-value
posterior fossa group B ependymoma 1530 2.73680170482676E-10
pilocytic astrocytoma 3086 3.34213263205744E-8
glioblastoma 5572 2.0013586300777E-7
sonic hedgehog group medulloblastoma 1482 2.53886593441126E-7
juvenile dermatomyositis 1189 6.33963146117802E-7
ovarian cancer 8492 6.69085906522498E-7
malignant mesothelioma 3163 4.07775704139631E-6
Duchenne muscular dystrophy 602 2.02133875508641E-5
atypical teratoid / rhabdoid tumor 4369 2.07795545036026E-5
pediatric high grade glioma 2712 2.4527912188923E-5
psoriasis 6685 2.67547084447156E-5
medulloblastoma, large-cell 6234 4.87867433796914E-5
limb girdle muscular dystrophy 2A 156 6.56242662390746E-5
primitive neuroectodermal tumor 3031 9.47736517638485E-5
lung cancer 4473 1.43364031757072E-4
osteosarcoma 7933 0.00134746672624984
dermatomyositis 967 0.00254247982267661
COPD 116 0.00305803655350026
pancreatic ductal adenocarcinoma liver metastasis 1795 0.0101871055603745
Disease Target Count Z-score Confidence
Vaccinia 37 5.474 2.7
Byssinosis 4 3.472 1.7

Expression

  Differential Expression (19)

Synonym

Accession P51452 D3DX45 Q5U0J1 Q8IYJ9
Symbols VHR

Gene

PDB

1J4X   1VHR   3F81  

  Ortholog (10)

Species Source
Chimp OMA EggNOG
Macaque OMA EggNOG Inparanoid
Mouse OMA EggNOG Inparanoid
Rat OMA EggNOG Inparanoid
Dog OMA EggNOG
Horse OMA EggNOG
Cow OMA EggNOG Inparanoid
Pig OMA EggNOG
Opossum OMA EggNOG Inparanoid
Anole lizard OMA EggNOG Inparanoid

MLP Assay (16)

AID Type Active / Inconclusive / Inactive Description
1654 confirmatory 1524 / 0 / 289641 uHTS absorbance assay for the identification of compounds that inhibit VHR1.
1661 summary 1 / 0 / 0 Summary of the absorbance assay for the identification of compounds that inhibit VHR1.
1878 confirmatory 195 / 0 / 853 Fluorescent assay for identification of compounds that inhibit VHR1
1957 confirmatory 36 / 0 / 40 SAR VHR1 Fluorescent Assay for In Vitro dose response studies
1958 confirmatory 26 / 0 / 25 SAR VHR1 absorbance Assay for In Vitro dose response studies.
1992 screening 347 / 0 / 49493 HTS Colorimetric assay for the identification of compounds that inhibit VHR1
2004 confirmatory 21 / 0 / 35 SAR Colorimetric assay for the identification of compounds that inhibit VHR1
2070 confirmatory 30 / 0 / 2 MOA VHR1 Fluorescent secondary assay for identification of redox-state modulating compounds
2074 confirmatory 9 / 0 / 0 SAR Fluorescence Assay for VHR1 Inhibitors using DiFMUP
2684 confirmatory 45 / 0 / 39 SAR VHR1 Fluorescent Assay for In Vitro dose response studies Set 2
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Gene RIF (16)

PMID Text
25876765 Our results demonstrate that DUSP3 plays a key and nonredundant role as a regulator of innate immune responses
24901344 Data suggest levels of gene expression of both DUSP3 (dual specificity phosphatase 3) and PSME3 (proteasome activator subunit 3) are associated with susceptibility to Staphylococcus aureus infection/sepsis in humans and in mouse disease model.
24886454 DUSP3 is a pro-angiogenic atypical dual-specificity phosphatase.
24798147 VHR can dimerize inside cells, and that VHR catalytic activity is reduced upon dimerization.
24245651 DUSP3 interacting partners are nucleolar proteins involved in processes related to DNA repair and senescence.
23918168 we report the first successful site-specific incorporation of sulfotyrisine into VHR through the use of expanding genetic code
23322772 Proteins containing the class II motifs are efficient VHR substrates in vitro, suggesting that VHR may act on a novel class of yet unidentified Tyr(P) proteins in vivo.
21921027 Enteric commensal bacteria induce extracellular signal-regulated kinase pathway signaling via formyl peptide receptor-dependent redox modulation of dual specific phosphatase 3
21262974 VHR expression enhances the signaling of ErbB receptors and may be involved in NSCLC pathogenesis.
19010898 VHR has a direct role in the inhibition of JNK-dependent apoptosis in LNCaP cells and may therefore have a role in prostate cancer progression.
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AA Sequence

MSGSFELSVQDLNDLLSDGSGCYSLPSQPCNEVTPRIYVGNASVAQDIPKLQKLGITHVLNAAEGRSFMH      1 - 70
VNTNANFYKDSGITYLGIKANDTQEFNLSAYFERAADFIDQALAQKNGRVLVHCREGYSRSPTLVIAYLM     71 - 140
MRQKMDVKSALSIVRQNREIGPNDGFLAQLCQLNDRLAKEGKLKP                             141 - 185
//

Text Mined References (40)

PMID Year Title
25876765 2015 DUSP3 Genetic Deletion Confers M2-like Macrophage-Dependent Tolerance to Septic Shock.
24901344 2014 Dusp3 and Psme3 are associated with murine susceptibility to Staphylococcus aureus infection and human sepsis.
24886454 2014 DUSP3/VHR is a pro-angiogenic atypical dual-specificity phosphatase.
24798147 2014 Unnatural amino acid mutagenesis reveals dimerization as a negative regulatory mechanism of VHR's phosphatase activity.
24531476 2014 The family-wide structure and function of human dual-specificity protein phosphatases.
24245651 2013 Proteomic, cellular, and network analyses reveal new DUSP3 interactions with nucleolar proteins in HeLa cells.
23918168 2013 A genetically encoded sulfotyrosine for VHR function research.
23376485 2013 Proteomic analysis of podocyte exosome-enriched fraction from normal human urine.
23322772 2013 Specificity profiling of dual specificity phosphatase vaccinia VH1-related (VHR) reveals two distinct substrate binding modes.
22572157 Sensitive detection of idiotypic platelet-reactive alloantibodies by an electrical protein chip.
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