Property Summary

NCBI Gene PubMed Count 18
PubMed Score 158.15
PubTator Score 362.59

Knowledge Summary


No data available


  Disease Sources (4)

Disease Target Count
Inflammatory Bowel Diseases 87
Disease Target Count P-value
posterior fossa group A ependymoma 1511 1.74832493533063E-11
medulloblastoma 1524 2.35218928687024E-6
atypical teratoid/rhabdoid tumor 1095 3.53409972091597E-6
ovarian cancer 8492 4.29627077779794E-5
pituitary cancer 1972 1.81432444281884E-4
Multiple myeloma 1328 0.0018207897838095
glioblastoma 5572 0.00340683966915162
esophageal adenocarcinoma 737 0.0180659511873377
subependymal giant cell astrocytoma 2287 0.0234735902800407
Disease Target Count Z-score Confidence
Crohn's disease 304 0.0 2.0
ulcerative colitis 2087 0.0 2.0
Disease Target Count Z-score Confidence
Cancer 2346 4.216 2.1


  Differential Expression (9)

Disease log2 FC p
Multiple myeloma 1.033 0.002
esophageal adenocarcinoma 1.100 0.018
posterior fossa group A ependymoma 1.600 0.000
medulloblastoma 1.200 0.000
glioblastoma 1.500 0.003
atypical teratoid/rhabdoid tumor 1.100 0.000
subependymal giant cell astrocytoma 1.840 0.023
ovarian cancer 1.800 0.000
pituitary cancer -1.200 0.000


Accession P51397 Q6FGC3 Q9BUC9 DAP-1



PANTHER Protein Class (1)

  Ortholog (8)

Species Source
Mouse OMA EggNOG Inparanoid
Rat OMA EggNOG Inparanoid
Cow OMA EggNOG Inparanoid
Opossum OMA EggNOG Inparanoid
Platypus OMA EggNOG Inparanoid
Chicken OMA EggNOG
Anole lizard OMA EggNOG Inparanoid
Xenopus OMA EggNOG Inparanoid

Pathway (1)

Gene RIF (6)

25530065 DAP1 may have an important role in cell adhesion, migration and growth in the context of breast cancer and has significant associations with the apoptosis pathway.
24270644 DAP1 was found to be correlated with disease progression and long-term survival of the colorectal patients. DAP1 is also a pivotal regulator of the growth and apoptosis and cellular response to chemotherapy agents.
22798505 This study demonstrates an inverse association between DAP1 mRNA levels and tumour stage and clinical outcome in breast cancer
20537536 Mapping of the phosphorylation sites and analysis of phosphorylation mutants indicated that DAP1 is functionally silenced in growing cells through mTOR-dependent phosphorylations on Ser3 and Ser51
20379614 Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
20237496 Observational study of gene-disease association. (HuGE Navigator)

AA Sequence

PPAAAQVAHQKPHASMDKHPSPRTQHIQQPRK                                           71 - 102

Text Mined References (23)

PMID Year Title
25944712 2015 N-terminome analysis of the human mitochondrial proteome.
25530065 2015 Effect of the knockdown of death-associated protein 1 expression on cell adhesion, growth and migration in breast cancer cells.
24270644 2014 Death associated protein 1 is correlated with the clinical outcome of patients with colorectal cancer and has a role in the regulation of cell death.
23934736 2013 Genome-wide association study of a heart failure related metabolomic profile among African Americans in the Atherosclerosis Risk in Communities (ARIC) study.
23186163 2013 Toward a comprehensive characterization of a human cancer cell phosphoproteome.
23128233 2012 Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
22798505 The mRNA expression of DAP1 in human breast cancer: correlation with clinicopathological parameters.
21406692 2011 System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
21297633 2011 Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47.
20537536 2010 DAP1, a novel substrate of mTOR, negatively regulates autophagy.