Property Summary

NCBI Gene PubMed Count 28
PubMed Score 142.91
PubTator Score 61.78

Knowledge Summary


No data available


  Disease Sources (1)

Disease Target Count P-value
atypical teratoid/rhabdoid tumor 1095 7.67763223081442E-12
pilocytic astrocytoma 3086 4.09925922127409E-11
adult high grade glioma 2148 1.80174606344121E-5
intraductal papillary-mucinous neoplasm (IPMN) 3289 1.90474332223906E-4
ependymoma 2514 4.75573783333239E-4
glioblastoma 5572 9.2934966527847E-4
lung carcinoma 2844 0.00197189443540313
interstitial cystitis 2299 0.00259021037057858
lung cancer 4473 0.00293289826309795
astrocytic glioma 2241 0.00479332520953155
group 3 medulloblastoma 2254 0.0078434256990841
ovarian cancer 8492 0.0152343933465952
oligodendroglioma 2849 0.0246403459584922
intraductal papillary-mucinous adenoma (IPMA) 2956 0.02898423416629
intraductal papillary-mucinous carcinoma (IPMC) 2988 0.0448708399912701
chronic rhinosinusitis 512 0.0477319801828594


  Differential Expression (16)


Accession P51161 Q07DR7 Q8TBI3 Q9UGI7 GT
Symbols ILBP



1O1U   1O1V   2MM3   5L8I   5L8N   5L8O  

  Ortholog (9)

Species Source
Chimp OMA EggNOG
Macaque OMA EggNOG Inparanoid
Mouse OMA EggNOG Inparanoid
Rat OMA EggNOG Inparanoid
Cow OMA EggNOG Inparanoid
Opossum EggNOG Inparanoid
Chicken OMA EggNOG Inparanoid
Anole lizard OMA EggNOG Inparanoid
Xenopus OMA EggNOG Inparanoid

Gene RIF (15)

26613247 Structural determinants of ligand binding in the ternary complex of human ileal bile acid binding protein with glycocholate and glycochenodeoxycholate obtained from solution NMR
25073073 Analysis of slow and fast motions in I-BABP indicates largely different energy landscapes for the apo and holo states suggesting that optimization of binding interactions might be achieved by altering the dynamic behavior of specific protein segments.
23758264 show, using electrospray ionization mass spectroscopy, that human ILBP binds bile acids with a 3:1 ratio, even at low protein and ligand concentrations
22329738 NMR data are in agreement with a conformational selection model we proposed earlier for I-BABP and support the hypothesis of an allosteric mechanism of ligand binding
22223860 Ursodeoxycholic acid induces unique conformational changes in IBABP.
20628086 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
19913121 Observational study of gene-disease association. (HuGE Navigator)
19744871 The-putative functional-Thr79Met substitution of FABP6 confers a protective effect on type 2 diabetes in obese individuals.
19744871 Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
17266179 Observational study of gene-disease association. (HuGE Navigator)

AA Sequence


Text Mined References (30)

PMID Year Title
26613247 2016 Structural determinants of ligand binding in the ternary complex of human ileal bile acid binding protein with glycocholate and glycochenodeoxycholate obtained from solution NMR.
25073073 2014 Temperature dependence of backbone dynamics in human ileal bile acid-binding protein: implications for the mechanism of ligand binding.
23758264 2013 Cooperativity and site selectivity in the ileal lipid binding protein.
22329738 2012 Internal motions and exchange processes in human ileal bile acid binding protein as studied by backbone (15)N nuclear magnetic resonance spectroscopy.
22223860 2012 Unusual binding of ursodeoxycholic acid to ileal bile acid binding protein: role in activation of FXR?.
20628086 2010 Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
19913121 2009 Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
19744871 2009 Evidence for the Thr79Met polymorphism of the ileal fatty acid binding protein (FABP6) to be associated with type 2 diabetes in obese individuals.
18029348 2008 Toward a confocal subcellular atlas of the human proteome.
17909007 2007 A novel variant of ileal bile acid binding protein is up-regulated through nuclear factor-kappaB activation in colorectal adenocarcinoma.