Property Summary

NCBI Gene PubMed Count 47
PubMed Score 49.72
PubTator Score 45.26

Knowledge Summary

Patent

No data available

TINX Plot

  Disease Sources (3)

Disease Target Count
Chronic Obstructive Airway Disease 47
Disease Target Count P-value
non-small cell lung cancer 2798 3.94758299929376E-20
oligodendroglioma 2849 1.53188158199664E-14
nasopharyngeal carcinoma 1056 2.40413555316585E-8
group 4 medulloblastoma 1875 2.20790477089949E-5
malignant mesothelioma 3163 3.15653951507041E-5
Pick disease 1893 8.3643967774331E-5
ovarian cancer 8492 1.00460779006249E-4
acute quadriplegic myopathy 1157 1.13379945059799E-4
invasive ductal carcinoma 2950 1.7339969995639E-4
medulloblastoma, large-cell 6234 1.73498143207835E-4
psoriasis 6685 2.42897684146177E-4
lung cancer 4473 2.60162776000419E-4
primitive neuroectodermal tumor 3031 0.00124635265251125
intraductal papillary-mucinous carcinoma (IPMC) 2988 0.00216138059253098
intraductal papillary-mucinous adenoma (IPMA) 2956 0.00227355046385472
chronic lymphocytic leukemia 244 0.0027535473076983
osteosarcoma 7933 0.00291461359298916
intraductal papillary-mucinous neoplasm (IPMN) 3289 0.0035431801826852
pancreatic ductal adenocarcinoma liver metastasis 1795 0.0118127380128477
astrocytic glioma 2241 0.0257010805603254
spina bifida 1064 0.035817889435841
Disease Target Count Z-score Confidence
sarcoidosis 368 4.631 2.3
Type 2 diabetes mellitus 192 0.0 1.0

Expression

Synonym

Accession P50995 B4DVE7
Symbols ANX11
CAP50

Gene

  Ortholog (12)

Species Source
Macaque OMA EggNOG Inparanoid
Mouse OMA EggNOG Inparanoid
Rat OMA EggNOG Inparanoid
Dog OMA EggNOG Inparanoid
Horse OMA EggNOG Inparanoid
Cow OMA EggNOG Inparanoid
Pig OMA EggNOG
Opossum EggNOG Inparanoid
Anole lizard OMA Inparanoid
Xenopus OMA Inparanoid
Zebrafish OMA Inparanoid
C. elegans OMA Inparanoid

Gene RIF (22)

PMID Text
25540196 findings suggest that AnxA11 maintains architectural and functional features of the ERES by coordinating with ALG-2 to stabilize Sec31A at the ERES.
25056970 These findings point to a role for the polymorphisms of ANXA11 in sarcoidosis in a Chinese Han population, and may be informative for future genetic studies on sarcoidosis.
24508622 the associations of Anxa11 with Ca(2+)-regulated exocytosis, cytokinesis, sex differentiation, autoimmune diseases, thrombolysis and cancers are summarized--{REVIEW}
24032725 Annexin A11 rs1049550*T allele exerts a significant protective effect on sarcoidosis susceptibility.
23579219 LIFR rs3729740 and possibly ANXA11 rs1049550 may be useful as biomarkers for predicting whether metastatic colorectal cancer patients are sensitive to relevant target regimens, although further validation in large cohorts is needed.
23151485 ANXA11 SNPs are associated with sarcoidosis in African Americans.
21562576 ANXA11 rs1049550 single nucleotide polymorphism is the susceptibility marker in sarcoidosis, at least in Caucasians.
20805159 Data confirm the strong association between variations in ANXA11 and sarcoidosis and support the hypothesis that ANXA11 represents a strong genetic risk factor for sarcoidosis.
20805159 Observational study of gene-disease association. (HuGE Navigator)
20093729 A7 and A11 have sequence repeats that form novel structures, called YP pro-beta helices, that are characterized by an ability to interact with one another
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AA Sequence

MSYPGYPPPPGGYPPAAPGGGPWGGAAYPPPPSMPPIGLDNVATYAGQFNQDYLSGMAANMSGTFGGANM      1 - 70
PNLYPGAPGAGYPPVPPGGFGQPPSAQQPVPPYGMYPPPGGNPPSRMPSYPPYPGAPVPGQPMPPPGQQP     71 - 140
PGAYPGQPPVTYPGQPPVPLPGQQQPVPSYPGYPGSGTVTPAVPPTQFGSRGTITDAPGFDPLRDAEVLR    141 - 210
KAMKGFGTDEQAIIDCLGSRSNKQRQQILLSFKTAYGKDLIKDLKSELSGNFEKTILALMKTPVLFDIYE    211 - 280
IKEAIKGVGTDEACLIEILASRSNEHIRELNRAYKAEFKKTLEEAIRSDTSGHFQRLLISLSQGNRDEST    281 - 350
NVDMSLAQRDAQELYAAGENRLGTDESKFNAVLCSRSRAHLVAVFNEYQRMTGRDIEKSICREMSGDLEE    351 - 420
GMLAVVKCLKNTPAFFAERLNKAMRGAGTKDRTLIRIMVSRSETDLLDIRSEYKRMYGKSLYHDISGDTS    421 - 490
GDYRKILLKICGGND                                                           491 - 505
//

Text Mined References (52)

PMID Year Title
25944712 2015 N-terminome analysis of the human mitochondrial proteome.
25724726 2015 Prostate cancer-associated autoantibodies in serum against tumor-associated antigens as potential new biomarkers.
25540196 2015 A new role for annexin A11 in the early secretory pathway via stabilizing Sec31A protein at the endoplasmic reticulum exit sites (ERES).
25056970 2014 Annexin A11 (ANXA11) gene polymorphisms are associated with sarcoidosis in a Han Chinese population: a case-control study.
24508622 2014 Annexin A11 in disease.
24275569 2014 An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
24032725 2013 Annexin A11 gene polymorphism (R230C variant) and sarcoidosis in a Portuguese population.
23579219 2013 Feasibility of proposed single-nucleotide polymorphisms as predictive markers for targeted regimens in metastatic colorectal cancer.
23533145 2013 In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine.
23376485 2013 Proteomic analysis of podocyte exosome-enriched fraction from normal human urine.
More...