Property Summary

NCBI Gene PubMed Count 53
PubMed Score 459.36
PubTator Score 351.71

Knowledge Summary


No data available


  Disease Sources (5)

Disease Target Count P-value
Duchenne muscular dystrophy 602 2.90983389612797E-8
tuberculosis 1563 2.63042340191653E-6
Multiple myeloma 1328 1.19835247760203E-5
ulcerative colitis 2087 5.27637267448986E-5
invasive ductal carcinoma 2950 0.0014427139896084
ovarian cancer 8492 0.00245261922209054
diabetes mellitus 1663 0.00447996342354068
astrocytoma 1493 0.00716006728556264
intraductal papillary-mucinous adenoma (IPMA) 2956 0.0129071535752292
Waldenstrons macroglobulinemia 765 0.017639362601681
Breast cancer 3099 0.0478188481059969
Disease Target Count Z-score Confidence
Blindness 84 3.875 1.9
Epilepsy 346 3.376 1.7


  Differential Expression (11)

Disease log2 FC p
Waldenstrons macroglobulinemia 1.731 0.018
Multiple myeloma 2.095 0.000
astrocytoma 1.100 0.007
Duchenne muscular dystrophy 1.050 0.000
tuberculosis 1.100 0.000
intraductal papillary-mucinous adenoma (... -1.100 0.013
diabetes mellitus -1.500 0.004
Breast cancer 2.100 0.048
invasive ductal carcinoma 1.200 0.001
ulcerative colitis 1.400 0.000
ovarian cancer 1.800 0.002


Accession P50897 B4DY24 Q6FGQ4 PPT-1
Symbols PPT


PANTHER Protein Class (2)



  Ortholog (13)

Species Source
Chimp OMA EggNOG
Macaque OMA EggNOG Inparanoid
Mouse OMA EggNOG Inparanoid
Rat OMA EggNOG Inparanoid
Dog OMA EggNOG Inparanoid
Cow OMA EggNOG Inparanoid
Opossum OMA EggNOG Inparanoid
Platypus OMA EggNOG
Chicken OMA EggNOG Inparanoid
Anole lizard OMA EggNOG Inparanoid
Xenopus OMA EggNOG Inparanoid
C. elegans OMA EggNOG Inparanoid
Fruitfly EggNOG Inparanoid

Gene RIF (20)

26731412 we reveal the existence of a positive feedback loop, where palmitoylation of PPT1 results in decreased activity and subsequent elevation in the amount of palmitoylated proteins.
25865307 analysis of the palmitoyl protein thioesterase 1 interactome in SH-SY5Y human neuroblastoma cells
25233404 Data (including data from knockout mice) suggest that deficiency of PPT1 leads to accumulation of granular osmiophilic deposits in many cell types, especially in astrocytes. [review-like article]
24083319 Data suggest that human monocytes and macrophages express PPT1; PPT1 appears to contribute 32-40% of 2-arachidonylglycerol hydrolysis activity in THP1 monocyte cell line.
22520356 This neuroimaging finding in PPT1-related neuronal ceroid lipofuscinosis was not previously reported.
21704547 Stop codon read-through with PTC124 induces palmitoyl-protein thioesterase-1 activity, reduces thioester load and suppresses apoptosis in cultured cells from Infantile neuronal ceroid lipofuscinosis patients.
19793631 Results describe the correlation between the three-dimensional structural changes in mutant palmitoyl protein thioesterase 1 and biochemical phenotypes.
19302939 study presents clinical and diagnostic investigations in six children with variant late infantile neuronal ceroid lipofuscinosis and mutations in CLN1 including a new large-scale deletion on one allele
19201763 Observational study of gene-disease association. (HuGE Navigator)
19165527 Using shotgun mass spectrometry, we found this protein differentially expressed in the dorsolateral prefrontal cortex from patients with schizophrenia.

AA Sequence

VFLATEGDHLQLSEEWFYAHIIPFLG                                                281 - 306

Text Mined References (58)

PMID Year Title
26731412 2016 Reversible Cysteine Acylation Regulates the Activity of Human Palmitoyl-Protein Thioesterase 1 (PPT1).
25944712 2015 N-terminome analysis of the human mitochondrial proteome.
25865307 2015 Proteomic analysis of the palmitoyl protein thioesterase 1 interactome in SH-SY5Y human neuroblastoma cells.
25233404 2014 Astrocytosis in infantile neuronal ceroid lipofuscinosis: friend or foe?
24275569 2014 An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
24083319 2013 Identification of palmitoyl protein thioesterase 1 in human THP1 monocytes and macrophages and characterization of unique biochemical activities for this enzyme.
23533145 2013 In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine.
23376485 2013 Proteomic analysis of podocyte exosome-enriched fraction from normal human urine.
22520356 2012 Novel neuroimaging finding in palmitoyl protein thioesterase-1-related neuronal ceroid lipofuscinosis.
21990111 2012 Update of the mutation spectrum and clinical correlations of over 360 mutations in eight genes that underlie the neuronal ceroid lipofuscinoses.