Property Summary

NCBI Gene PubMed Count 693
Grant Count 173
R01 Count 106
Funding $20,372,073.25
PubMed Score 627.14
PubTator Score 3727.70

Knowledge Summary

Patent

No data available

TINX Plot

  Disease Relevance (60)

Disease Z-score Confidence
Cancer 2,346 5.486 2.7
Atopic dermatitis 944
COPD 113
Colonic Neoplasms 126
Colorectal Neoplasms 217
Duchenne muscular dystrophy 602
Endometrial Neoplasms 50
Endometriosis 535
Gaucher disease type 3 76
Glioma 65
Influenza 142
Kidney Neoplasm 27
Leukemia 88
Leukemia, Myelocytic, Acute 113
Liver carcinoma 217
Liver neoplasms 109
Mammary Neoplasms 410
Mammary Neoplasms, Experimental 150
Multiple Sclerosis 498
Multiple myeloma 1,327
Neoplasm Metastasis 138
Neoplasms, Experimental 33
Neuroblastoma 78
Pancreatic Neoplasm 79
Pathologic Neovascularization 6
Prostatic Neoplasms 471
Renal Cell Carcinoma 199
Spontaneous abortion 108
active Crohn's disease 918
active ulcerative colitis 477
adrenocortical carcinoma 1,427
aldosterone-producing adenoma 664
atypical teratoid / rhabdoid tumor 4,369
colon cancer 1,475
cutaneous lupus erythematosus 1,056
cystic fibrosis 1,665
ependymoma 2,514
glioblastoma 5,572
hepatocellular carcinoma 532
intraductal papillary-mucinous adenoma (... 2,956 
intraductal papillary-mucinous carcinoma... 2,988 
intraductal papillary-mucinous neoplasm ... 3,289 
juvenile dermatomyositis 1,189
lung cancer 4,466
lung carcinoma 2,844
malignant mesothelioma 3,162
mucosa-associated lymphoid tissue lympho... 480 
oligodendroglioma 2,849
ovarian cancer 8,484
ovarian neoplasm 97
pancreatic cancer 2,300
pediatric high grade glioma 2,712
pilocytic astrocytoma 3,086
pituitary cancer 1,972
primary pancreatic ductal adenocarcinoma 1,271
primitive neuroectodermal tumor 3,031
psoriasis 6,685
sonic hedgehog group medulloblastoma 1,482
subependymal giant cell astrocytoma 2,287
tuberculosis 1,557

Expression

Synonym

Accession P50591 A1Y9B3
Symbols TL2
APO2L
CD253
TRAIL
Apo-2L
TNLG6A

Gene

PDB

1D0G   1D2Q   1D4V   1DG6   1DU3   4N90  

 IMPC Term (1)

MLP Assay (15)

AID Type Active / Inconclusive / Inactive Description
1443 screening 883 / 0 / 216304 uHTS for the identification of compounds that potentiate TRAIL-induced apoptosis of cancer cells
1624 confirmatory 3 / 0 / 0 Confirmation screening of compounds that potentiate TRAIL-induced apoptosis of cancer cells.
1640 summary 2 / 0 / 0 Summary of compounds that potentiate TRAIL-induced apoptosis of cancer cells.
1745 other 0 / 0 / 3 Confirmation screening of compounds that potentiate TRAIL-induced apoptosis in normal 184B5 cells
1746 other 3 / 0 / 0 Confirmation screening of compounds that potentiate TRAIL-induced apoptosis in primary human hepatocytes.
1747 other 3 / 0 / 0 Confirmation screening of compounds that potentiate TRAIL-induced apoptosis in TRAIL-resistant cancer cells, MDA-MB-435
1748 other 1 / 0 / 2 Confirmation screening of compounds that potentiate TRAIL-induced apoptosis in TRAIL-resistant cancer cells, MCF7
1752 confirmatory 3 / 0 / 7 SAR analysis of compounds that potentiate TRAIL-induced apoptosis in PPC-1 cells.
1755 confirmatory 3 / 0 / 7 SAR analysis of compounds that potentiate TRAIL-induced apoptosis in MDA-MB-435 cells.
1765 other 2 / 0 / 1 Mechanism of action of compounds that potentiate TRAIL-induced apoptosis in PPC-1 cells
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Gene RIF (680)

PMID Text
26962689 NGF FLIPs TrkA onto the death TRAIL in neuroblastoma cells
26871575 HMGB1 as a trigger for IFN-alpha-mediated TRAIL expression at the surface of Plasmacytoid dendritic cells (pDCs) and Natural Killer (NK) Cells, and they suggest a novel mechanism of innate control of HIV-1 infection.
26841509 NF-kB Activation Inhibitor IV and JSH-23 reduced resistance in the acute myeloid leukemia cells in multicellular aggregates to cytotoxic action of recombinant protein izTRAIL.
26802603 Smad2 enhances TRAIL-induced apoptosis in activated hepatic stellate cells, which facilitates the resolution of hepatic fibrosis
26792723 Collectively, these studies define Sig1R as a key mediator of TRAIL induction of cancer-specific killing.
26721202 Valproic acid sensitized TRAIL-resistant papillary thyroid carcinoma cells to apoptotic cell death through involvement of Nrf2 and Bcl-xL.
26720004 Bay 61-3606 downregulates Mcl-1 expression in breast cancer cells and sensitizes cancer cells to TRAIL-mediated apoptosis.
26718429 TRAIL genetic polymorphisms do not contribute, but DR4 polymorphisms may contribute to susceptibility to head and neck cancer in Pakistani population.
26648023 Our findings suggested that GA induces apoptosis via the downregulation of cFLIPL and sensitized TRAIL-mediated apoptosis in Caki cells.
26633016 showed that the level of blood cholesterol was significantly higher in subjects in the upper quartile of serum TRAIL. In conclusion, our data demonstrate that the serum TRAIL concentration is elevated in people with hypercholesterolemia
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AA Sequence

MAMMEVQGGPSLGQTCVLIVIFTVLLQSLCVAVTYVYFTNELKQMQDKYSKSGIACFLKEDDSYWDPNDE      1 - 70
ESMNSPCWQVKWQLRQLVRKMILRTSEETISTVQEKQQNISPLVRERGPQRVAAHITGTRGRSNTLSSPN     71 - 140
SKNEKALGRKINSWESSRSGHSFLSNLHLRNGELVIHEKGFYYIYSQTYFRFQEEIKENTKNDKQMVQYI    141 - 210
YKYTSYPDPILLMKSARNSCWSKDAEYGLYSIYQGGIFELKENDRIFVSVTNEHLIDMDHEASFFGAFLV    211 - 280
G//

Text Mined References (696)

PMID Year Title
26962689 2016 NGF FLIPs TrkA onto the death TRAIL in neuroblastoma cells.
26871575 2016 HMGB1 Is Involved in IFN-? Production and TRAIL Expression by HIV-1-Exposed Plasmacytoid Dendritic Cells: Impact of the Crosstalk with NK Cells.
26841509 [Inhibition of NF-kB Activation Decreases Resistance in Acute Myeloid Leukemia Cells to TRAIL-induced Apoptosis in Multicellular Aggregates].
26802603 2016 Smad2 increases the apoptosis of activated human hepatic stellate cells induced by TRAIL.
26792723 2016 Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) activates caspases in human prostate cancer cells through sigma 1 receptor.
26721202 2016 Downregulation of Nrf2 by the combination of TRAIL and Valproic acid induces apoptotic cell death of TRAIL-resistant papillary thyroid cancer cells via suppression of Bcl-xL.
26720004 2015 Bay 61-3606 Sensitizes TRAIL-Induced Apoptosis by Downregulating Mcl-1 in Breast Cancer Cells.
26718429 2015 Genetic variants in the tumor Necrosis Factor-Related Apoptosis-Inducing Ligand (TRAIL) do not contribute but Death Receptor (DR4) genes may contribute to susceptibility to head and neck cancer in Pakistani population.
26648023 2016 Gambogic acid induces apoptosis and sensitizes TRAIL-mediated apoptosis through downregulation of cFLIPL in renal carcinoma Caki cells.
26646413 2016 Comparative genomic analysis of eutherian tumor necrosis factor ligand genes.
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